McGaughy J, Dalley JW, Morrison CH, Everitt BJ, Robbins TW (2002) Selective behavioral and neurochemical effects of cholinergic lesions produced by intrabasalis infusions of 192 IgG-saporin on attentional performance in a five-choice serial reaction time task. J Neurosci 22(5):1905-1913. doi: 10.1523/JNEUROSCI.22-05-01905.2002
Summary: 192-Saporin (Cat. #IT-01) has been a very useful tool in determining the role of the basal forebrain cholinergic system in arousal and attention tasks. The authors lesioned the nucleus basalis magnocellularis of rats with an infusion of 0.5 µl per hemisphere of 0.15 µg/µl or 0.45 µg/µl 192-Saporin. The data show a correlation between the extent of the lesion and the amount of impairment in an attentional task. The authors also found that the accuracy deficits in the task could be ameliorated by lengthening the stimulus time, or exacerbated by increasing the event rate. Taken together the data indicate a direct relationship between basal forebrain damage and impaired attentional function.
Related Products: 192-IgG-SAP (Cat. #IT-01)