Lehmann O, Bertrand F, Jeltsch H, Morer M, Lazarus C, Will B, Cassel JC (2002) 5,7-DHT-induced hippocampal 5-HT depletion attenuates behavioural deficits produced by 192 IgG-saporin lesions of septal cholinergic neurons in the rat. Eur J Neurosci 15(12):1991-2006. doi: 10.1046/j.1460-9568.2002.02037.x
Summary: Although past data has shown that the cholinergic system of the basal forebrain is intrinsic to learning and memory, more recent data suggests that other neurotransmitter systems are also involved, perhaps serving modulatory functions. The authors used 5,7-DHT injections alone or with intraseptal 192-Saporin (Cat #IT-01, 0.4 µg/side) injections in rats. The results demonstrate that serotonergic denervation of the hippocampus attenuates deficits produced by a cholinergic denervation of the septal region of the basal forebrain.
Usage: The authors used 192-Saporin, 0.4 µg/side intraseptal (Cat. #IT-01).
Related Products: 192-IgG-SAP (Cat. #IT-01)