Galani R, Lehmann O, Bolmont T, Aloy E, Bertrand F, Lazarus C, Jeltsch H, Cassel JC (2002) Selective immunolesions of CH4 cholinergic neurons do not disrupt spatial memory in rats. Physiol Behav 76:75-90. doi: 10.1016/s0031-9384(02)00674-1
Summary: Lesioning of the nucleus basalis magnocellularis (NBM) with 192-Saporin (Cat. #IT-01) has produced varied cognitive effects in numerous studies. The authors of this work suggest that several factors such as lesion procedure and the type of behavioral test used may cause these variations. Thirty-one rats were lesioned using 0.2 or 0.4 µg of 192-Saporin infused into the NBM, and locomotor activity, learning, and memory capabilities were tested using several test methods. Spatial memory appeared to remain intact, but evidence suggests that attentional processing is affected by NBM lesioning with 192-Saporin.
Usage: Rat NBM was lesioned using 0.2 or 0.4 µg of 192-Saporin (Cat. #IT-01).
Related Products: 192-IgG-SAP (Cat. #IT-01)