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  4. Selective lesions of basal forebrain cholinergic neurons produce anterograde and retrograde deficits in a social transmission of food preference task in rats.

Selective lesions of basal forebrain cholinergic neurons produce anterograde and retrograde deficits in a social transmission of food preference task in rats.

Vale-Martinez A, Baxter MG, Eichenbaum H (2002) Selective lesions of basal forebrain cholinergic neurons produce anterograde and retrograde deficits in a social transmission of food preference task in rats. Eur J Neurosci 16(6):983-998. doi: 10.1046/j.1460-9568.2002.02153.x

Summary: Injections of 0.2 µg 192-Saporin (Cat. #IT-01) were made into either the medial septum/vertical limb of the diagonal band (MS/VDB), or the nucleus basalis magnocellularis/substantia innominata (NBM/SI) of rats. MS/VDB lesions had no effect on anterograde memory, while NBM/SI lesions strongly impaired immediate and 24-hour retention. In contrast, MS/DVB lesions produced significant memory deficits in a long-delay retrograde memory test.

Related Products: 192-IgG-SAP (Cat. #IT-01)

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