tt2014

Targeting Trends 2014 Newsletter

Read the 2014 Newsletters Recent Scientific References 2014, issue 1: FDA Gives Green Light to Human Clinical Trials for Cancer Pain / by DA Lappi / featuring SP-SAP Targeting Talk: Time Course Targeting Tools: Investigating the Itch Pathway 2014, issue 2: Celebrating Twenty Years of Science Advanced Targeting Systems (founded 22 Apr 1994) / featuring 192-IgG-SAP, SP-SAP, Bombesin-SAP Celebrating …

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Otis Gets His Wag Back!

Dog with bone cancer jumps for joy over new treatment that made him pain-free after one dose! Otis, the golden retriever, was in his golden years when bone cancer pain threatened to shorten his life. As a participant in a clinical trial aimed at pet dogs, he was given a single treatment with a pain …

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Cancer Pain Relief in Pet Dogs has Direct Translation into Human Chronic Pain Conditions

Based on the recent publication by: Brown DC, Agnello K. (2013) Intrathecal substance p-saporin in the dog: efficacy in bone cancer pain. Anesthesiology 119(5):1178-1185 and the October 2013 press release by the American Society of Anesthesiologists, “Man’s best friends’ chronic pain relieved with new treatment, study finds: Findings could be useful to human cancer patients.” …

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Cover Article: Corticotropin releasing factor-saporin conjugate selectively lesions nucleus incertus.

Contributed by Corinne Liying Lee, Ramamoorthy Rajkumar, Gavin Stewart Dawe, Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System; Neurobiology and Ageing Programme, Life Sciences Institute, National University of Singapore; and Singapore Institute for Neurotechnology (SINAPSE), Singapore 117456 The nucleus incertus (NI) is a distinct group of cells in the pontine …

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Targeting Tools: Top Twenty

Top Five Targeted Toxins #1. 192-IgG-SAP (192-Saporin) (Cat. #IT-01) targets cells expressing rat p75NTR #2. Anti-DBH-SAP (Cat. #IT-03) targets cells expressing rat dopamine beta-hydroxylase (DBH) #3. mu p75-SAP (Cat. #IT-16) targets cells expressing mouse p75NTR #4. IB4-SAP (Cat. #IT-10) targets cells expressing α-D-galactopyranoside residues #5. Mac-1-SAP mouse/human (Cat. #IT-06) targets cells expressing mouse / human …

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Cover Article: Celebrating Twenty Years of Science Advanced Targeting Systems (founded 22 Apr 1994)

Advanced Targeting Systems’ first product, 192-IgG-SAP, answered a long-sought request from behavioral neuroscientists: a neurotoxin for the cholinergic neurons of the basal forebrain. Over the years it has become the classic in the field and has changed the way that we think about those neurons and their role in learning and memory. Substance P-saporin (SP-SAP) …

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Targeting Topics Top 20

Kilgard MP, Merzenich MM. (1998) Cortical map reorganization enabled by nucleus basalis activity. Science 279(5357):1714-1718. (Cat. #IT-01) – 888 citations Lu J, Sherman D, Devor M, Saper CB. (2006) A putative flip-flop switch for control of REM sleep. Nature 441(7093):589-594. (Cat. #IT-20) – 494 citations Mantyh PW, Rogers SD, Honore P, Allen BJ, Ghilardi JR, …

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