Targeting Trends 2014 Newsletter
Read the 2014 Newsletters and recent scientific references 2014, issue 1: 2014, issue 2: 2014, issue 3: 2014, issue 4:
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tt2014
Targeting Tools: ZAP Biotin-Z Internalization Kit
Targeted conjugates are widely used to escort payloads to specific cell populations in vitro and in vivo for both basic research and pharmaceutical development. Desirable traits of a Targeting Agent include high specificity and rapid internalization. The Targeting Agent can be an antibody, peptide, protein, or any other molecule that recognizes a cell- surface marker.
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Otis Gets His Wag Back!
Dog with bone cancer jumps for joy over new treatment that made him pain-free after one dose! Otis, the golden retriever, was in his golden years when bone cancer pain threatened to shorten his life. As a participant in a clinical trial aimed at pet dogs, he was given a single treatment with a pain
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Cancer Pain Relief in Pet Dogs has Direct Translation into Human Chronic Pain Conditions
Based on the recent publication by: Brown DC, Agnello K. (2013) Intrathecal substance p-saporin in the dog: efficacy in bone cancer pain. Anesthesiology 119(5):1178-1185 and the October 2013 press release by the American Society of Anesthesiologists, “Man’s best friends’ chronic pain relieved with new treatment, study finds: Findings could be useful to human cancer patients.”
Targeting Tools: ZAP Kit – How does it work?
Screening large numbers of antibodies for the ability to internalize can be prohibitively expensive in both cost and time. The ZAP Antibody Internalization Kit contains all the components needed for three 96-well plates, or 288 tests. The ability to perform a diagnostic screen that is amenable to high-throughput methods, prior to direct conjugation of those
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Cover Article: Corticotropin releasing factor-saporin conjugate selectively lesions nucleus incertus.
Contributed by Corinne Liying Lee, Ramamoorthy Rajkumar, Gavin Stewart Dawe, Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System; Neurobiology and Ageing Programme, Life Sciences Institute, National University of Singapore; and Singapore Institute for Neurotechnology (SINAPSE), Singapore 117456 The nucleus incertus (NI) is a distinct group of cells in the pontine
Targeting Tools: Top Twenty
Top Five Targeted Toxins #1. 192-IgG-SAP (192-Saporin) (Cat. #IT-01) targets cells expressing rat p75NTR #2. Anti-DBH-SAP (Cat. #IT-03) targets cells expressing rat dopamine beta-hydroxylase (DBH) #3. mu p75-SAP (Cat. #IT-16) targets cells expressing mouse p75NTR #4. IB4-SAP (Cat. #IT-10) targets cells expressing α-D-galactopyranoside residues #5. Mac-1-SAP mouse/human (Cat. #IT-06) targets cells expressing mouse / human
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Cover Article: Celebrating Twenty Years of Science Advanced Targeting Systems (founded 22 Apr 1994)
Advanced Targeting Systems’ first product, 192-IgG-SAP, answered a long-sought request from behavioral neuroscientists: a neurotoxin for the cholinergic neurons of the basal forebrain. Over the years it has become the classic in the field and has changed the way that we think about those neurons and their role in learning and memory. Substance P-saporin (SP-SAP)
Targeting Tools: Investigating the Itch Pathway
Bombesin-SAP (Cat. #IT-40) Bombesin is a 14-amino-acid peptide found in frog-skin. The human equivalent, gastrin releasing peptide (GRP) has been detected in itch pathways and plays a role in eating behaviors. GRP regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation.
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