tt2007

Targeting Tools: Anti-AChR

Species Reactivity: Human, Rat, Mouse, Rabbit Anti-AChR (Cat. #AB-N36) binds with high affinity to the AChR subtype with 59 kDa ACh-binding subunits, but with considerably lower affinity to the AChR subtype with 75 kDa subunits. Anti-AChR binds to the main immunogenic region on α1 subunits of muscle-type AChRs. Reference 1. Schoepfer R, Halvorsen SW, Conroy …

Targeting Tools: Anti-AChR Read More »

Targeting Trends 2007 Newsletter

2007, issue 1: Cholinergic Immunolesioning Produced Tangle-like Inclusions in TgCRND8 Brain / by Chauhan N / featuring mu p75-SAP (Cat. #IT-16) SFN Poster of the Year Targeting Talk: Targeted Toxin Controls Targeting Tools Anti-Pseudomonas aeurginosa (Cat. #AB-T057) Anti-Conjugated Glutathione (Cat. #AB-T01) Anti-Conjugated Acetylcholine (Cat. #AB-T02) Anti-Conjugated Dopamine (Cat. #AB-T11) Anti-CRH/CRF (Cat. #AB-02) Anti-basic FGF (Cat. #AB-07, Cat. #AB-08) …

Targeting Trends 2007 Newsletter Read More »

Targeting Topics 07q4

Cortical cholinergic deficiency enhances amphetamine-induced dopamine release in the accumbens but not in the striatum Mattsson A, Olson L, Svensson TH, Schilstrom B Exp Neurol 208(1):73-79, 2007. Previous data have implicated cholinergic dysfunction in the pathogenesis of schizophrenia. Here the authors investigated whether increased amphetamine-induced release of dopamine was a response to cortical cholinergic denervation. …

Targeting Topics 07q4 Read More »

Cover Article: Inducing Central Sensitization with a Substance P/ Cholera Toxin Conjugate

Contributed by Robert M. Caudle, Ph.D.University of Florida College of Dentistry, Gainesville, FL 32610 A substantial amount of work with Advanced Targeting Systems’ substance P/saporin conjugate (SP-SAP, Cat. #IT-07) has demonstrated that neurokinin-1 (NK1) receptor-expressing neurons in the spinal cord and brain stem are necessary for the full expression of central sensitization following a peripheral …

Cover Article: Inducing Central Sensitization with a Substance P/ Cholera Toxin Conjugate Read More »

New Targets: The Claustrum

What is the claustrum? The simple answer is that it’s a brain structure that lies under the insular and piriform cortices. What it does is rather unclear, but one hypothesis has drawn considerable attention. The claustrum contains projections to the entire cortex, and this may indicate that it plays an important role in brain function.  …

New Targets: The Claustrum Read More »

Targeting Tools: Targeting B-Cell Leukemias and Lymphomas

Anti-CD22 (UV22-2) Mouse Monoclonal This IgG1k antibody (Cat. #AB-36) recognizes the group A epitope of the human B-cell antigen, CD22. Clone UV22-2 reacts exclusively with cells of human B-cell lineage. The fluorescent conjugate mouse IgG-FITC (Cat. #FL-07) is available as a research tool to use with this and other mouse monoclonal antibodies. Anti-CD22-SAP Immunotoxin This …

Targeting Tools: Targeting B-Cell Leukemias and Lymphomas Read More »

Targeting Talk: Disposal, Sterilization, Intrastriatal Administration, and Activation

Your targeted toxin data sheet gives the following instruction for disposal: “Care in disposal is mandatory; autoclaving or exposure to 1 M sodium hydroxide will inactivate the material. All labware that comes into contact with this material should be likewise treated.” I am wondering if I can deactivate saporin by using 10% bleach or if …

Targeting Talk: Disposal, Sterilization, Intrastriatal Administration, and Activation Read More »