tt2007

Targeting Tools: Anti-AChR

Species Reactivity: Human, Rat, Mouse, Rabbit Anti-AChR (Cat. #AB-N36) binds with high affinity to the AChR subtype with 59 kDa ACh-binding subunits, but with considerably lower affinity to the AChR subtype with 75 kDa subunits. Anti-AChR binds to the main immunogenic region on α1 subunits of muscle-type AChRs. Reference 1. Schoepfer R, Halvorsen SW, Conroy …

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Targeting Trends 2007 Newsletter

Read the 2007 Newsletters and recent scientific references 2007, issue 1: Cholinergic Immunolesioning Produced Tangle-like Inclusions in TgCRND8 Brain / by Chauhan N / featuring mu p75-SAP (Cat. #IT-16) SFN Poster of the Year Targeting Talk: Targeted Toxin Controls Targeting Tools Anti-Pseudomonas aeurginosa (Cat. #AB-T057) Anti-Conjugated Glutathione (Cat. #AB-T01) Anti-Conjugated Acetylcholine (Cat. #AB-T02) Anti-Conjugated Dopamine (Cat. #AB-T11) …

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Cover Article: Inducing Central Sensitization with a Substance P/ Cholera Toxin Conjugate

Contributed by Robert M. Caudle, Ph.D.University of Florida College of Dentistry, Gainesville, FL 32610 A substantial amount of work with Advanced Targeting Systems’ substance P/saporin conjugate (SP-SAP, Cat. #IT-07) has demonstrated that neurokinin-1 (NK1) receptor-expressing neurons in the spinal cord and brain stem are necessary for the full expression of central sensitization following a peripheral …

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New Targets: The Claustrum

What is the claustrum? The simple answer is that it’s a brain structure that lies under the insular and piriform cortices. What it does is rather unclear, but one hypothesis has drawn considerable attention. The claustrum contains projections to the entire cortex, and this may indicate that it plays an important role in brain function.  …

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Targeting Tools: Targeting B-Cell Leukemias and Lymphomas

Anti-CD22 (UV22-2) Mouse Monoclonal This IgG1k antibody (Cat. #AB-36) recognizes the group A epitope of the human B-cell antigen, CD22. Clone UV22-2 reacts exclusively with cells of human B-cell lineage. The fluorescent conjugate mouse IgG-FITC (Cat. #FL-07) is available as a research tool to use with this and other mouse monoclonal antibodies. Anti-CD22-SAP Immunotoxin This …

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Targeted Therapy for Chronic Pain

In 1997, SP-SAP (a chemical conjugate of Substance P and the ribosome-inactivating protein saporin) was created to eliminate Substance P receptor (SPR) neurons that propagate the signal for chronic pain. ATS has successfully completed preclinical studies, safety tests in animal models and a GLP toxicology study in rat, funded both internally and by the National …

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New Targets: Insula Receptors

In the January 26 issue of Science there was an article by Naqvi et al. about patients with brain damage to the insula losing their desire to smoke. A podcast interview with Dr. Bechara, one of the authors of the study, ended with him stating that there are a number of known receptors in the brain that should be …

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Targeting Tools: Goat-ZAP

Goat-ZAP (Cat. #IT-36) is a new secondary conjugate of affinity-purified rabbit anti-goat IgG and the ribosome-inactivating protein, saporin. This product uses affinity-purified rabbit anti-goat IgG to “piggyback” onto YOUR primary goat antibody in order to evaluate the ability of your primary antibody to internalize. Once the conjugate is internalized, saporin breaks away from the targeting …

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