FGF-2, or basic fibroblast growth factor, binds all of the FGF receptors with high affinity. We have used this molecule to produce FGF-SAP (Cat. #IT-38), which has a healthy experimental publication record (“FGF” and “saporin” in PubMed: 25 hits). It has been used to clean primary cultures of fibroblasts. It was important in determining the role of smooth muscle cells in restenosis of damaged vasculature. It was widely used in vivo for the elimination of FGF receptor-expressing cells, including neuronal cell types, cancer cells, and lens epithelial cells. Figure 1 shows the cytotoxicity of ATS’ rat FGF-SAP conjugate to mouse NIH3T3 cells, with a potent ED50 of 68 pM. This conjugate will be useful for the study of systems biology.
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