ATS has added three new products to our fluorescent conjugates line. Alexa488-labeled affinity purified NGFr* (Cat. #FL-N01AP) FITC-labeled Goat Anti-Rat IgG (Cat. #FL-10) FITC-labeled Donkey Anti-Goat IgG (Cat. #FL-11) *(Cat. #AB-N01AP) These conjugates are excellent tools to verify specific binding to an antigen. By first incubating cells with the primary antibody, and then binding the …
Substance P-Saporin (SP-SAP) is a drug candidate that eliminates the spinal cord neurons that send the chronic pain signal to the brain. SP-SAP has been tested in a variety of animal models and proven effective in permanently eliminating the perception of chronic pain. ATS has completed extensive preclinical studies, a GLP toxicology study, and a …
Contributed by Jeffrey T. Potts, Ph.D., Department of Biomedical Science, College of Veterinary Medicine, Dalton Cardiovascular Research Center, Columbia, MO 65211 The nucleus tractus solitarii (NTS) receives afferent input from visceral, somatic and cardiopulmonary structures and is the first central site for the processing of these sensory autonomic signals. Modulation of sensory neurotransmission has been well …
Anti-Pseudomonas aeruginosa, Cat. #AB-T057 Pseudomonas aeruginosa is a Gram-negative bacterium that causes many infections, particularly in people with cystic fibrosis, burn victims, individuals with cancer and others who are immunosuppressed. This bacterium is studied by scientists not only because of its ability to cause disease and resist antibiotics, but also its metabolic capability and environmental …
Anti-Conjugated Glutathione, Cat. #AB-T01 Glutathione is a small protein composed of three amino acids: cysteine, glutamic acid, and glycine. The primary biological function of glutathione is to act as a non-enzymatic reducing agent. Glutathione is also involved in detoxification. Anti-Conjugated Glutathione targets conjugated glutathione which is created by fixation in glutaraldehyde. Applications include ELISA and …
Anti-Conjugated Acetylcholine, Cat. #AB-T02 Acetylcholine is a neurotransmitter found in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans. Anti-Conjugated Acetylcholine targets conjugated choline-glutaric acid which is created by fixation in glutaraldehyde. Applications include ELISA and immunohistochemistry.
Anti-Conjugated Dopamine, Cat. #AB-T11 Dopamine is a neurotransmitter found in various areas of the central and peripheral nervous system. Dopamine and its agonists play an important role in cardiovascular, renal, hormonal, and central nervous system regulation. Anti-Conjugated Dopamine targets conjugated dopamine which is created by fixation in glutaraldehyde. Applications include ELISA, immunocytochemistry, immunohistochemistry, and immunoblotting.
Anti-CRH/CRF, Cat. #AB-02 Corticotropin-releasing hormone/factor (CRH/CRF) is the principal neuropeptide involved in regulating the stress response. It stimulates ACTH release from the pituitary gland. When centrally administered to animals it produces somatic changes analogous to those seen in both depression and anxiety. In humans, it is capable of reproducing the hormonal changes which are characteristically …
Anti-basic FGF (FGF-2), Cat. #AB-07, Cat. #AB-08 Basic Fibroblast Growth Factor (FGF-2) is a 155-amino-acid protein (154 amino acids in rat) that has wide-ranging effects in a variety of systems. FGF-2 (also known as basic FGF) can induce proliferation of fibroblasts, endothelial cells, chondrocytes, smooth muscle cells, melanocytes, and other cell types. FGF-2 also has …
Contributed by Neelima Chauhan, Dept Anesthes/Anat & Cell Bio, Univ Illinois-Chicago;J. Brown VA Med Ctr Chicago, Chicago, IL and winner of the 2006 SfN Poster Award for work using ATS products. Today’s Alzheimer’s disease (AD) research lacks a “complete” model that would represent both plaque and tangle pathology together with correlative memory deficits. The currently …