Search Results for: IT-27

Cytoplasmic Delivery of Aptamers

Targeting Topics /

Screening Aptamers as Targeting Agents to deliver Payloads. Aptamers are small, synthetic, single-stranded nucleic acids that fold into unique secondary structures. Unlike peptides and monoclonal antibodies, they are essentially non-immunogenic even when administered in excess amounts. The publications below explain how biotinylated aptamers combined with Streptavidin-conjugated saporin (Streptavidin-ZAP) can be used to screen aptamers for […]

Cytoplasmic Delivery of Aptamers Read More »

ZAP Kits

Secondary Conjugate ZAP Internalization Kits ZAP conjugates are non-targeted saporin conjugates that “piggyback” on to your primary targeting agent (biotinylated material or antibody). The Biotin-Z Internalization Kits and ZAP Antibody Internalization Kits convert your material into a targeted toxin to eliminate specific cells and reveal cell function with definitive results. Choose Your Kit Antibody Peptide

ZAP Kits Read More »

Cover Article: Targeted depletion of hematopoietic stem cells promises safer transplantation

News Article /

By Rahul Palchaudhuri, Ph.D., Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA Hematopoietic stem cell transplantation (HSCT) has been clinically used for 58 years and offers life-saving therapies for a variety of malignant and non-malignant blood disorders. Currently 50,000 transplants are performed globally per year with 90% of these for the

Cover Article: Targeted depletion of hematopoietic stem cells promises safer transplantation Read More »

Targeting Tools: Product Managers Highlight Their Products

News Tools /

While recombinant IB4-SAP (rIB4-SAP, Cat. #IT-10) has traditionally been used to eliminate cell populations that display alpha-D-galactose on the cell membrane, such as non-peptidergic c-fiber nociceptor neurons, it has also been found to be a very effective way to create stable transfected cell lines without the use of drug resistance genes. A recent publication by

Targeting Tools: Product Managers Highlight Their Products Read More »

Cover Article: Selective deletion of CD8+ T cells by saporin-coupled MHC class I tetramers

News Article /

Contributed by Paul R. Hess, Adam S. Buntzman, Sabrina L. Murray, Ellen F. Young, and Jeffrey A. Frelinger;North Carolina State University College of Veterinary Medicine, Raleigh, NC;and University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, NC CD8+ T cells constitute important effectors of the adaptive immune response, functioning principally to remove infected cells

Cover Article: Selective deletion of CD8+ T cells by saporin-coupled MHC class I tetramers Read More »

Cover Article: Depletion of syndecan-4+ T lymphocytes by saporin-conjugated DC-HIL alleviates T cell-mediated imflammatory disease

News Article /

Contributed by Kiyoshi Ariizumi, Hideo Akiyoshi, Jin-Sung Chung, Mizuki Tomiharu, Ponciano D. Cruz Jr. Department of Dermatology, The University of Texas Southwestern Medical Center and Dermatology Section (Medical Service), Dallas Veterans Affairs Medical Center, Dallas, TX T lymphocyte activation is regulated by stimulatory and inhibitory signals transduced by binding of T cell receptors to corresponding

Cover Article: Depletion of syndecan-4+ T lymphocytes by saporin-conjugated DC-HIL alleviates T cell-mediated imflammatory disease Read More »

Chemical design of a supramolecular protein nanoplatform for therapeutic applications

Heck AJ (2023) Chemical design of a supramolecular protein nanoplatform for therapeutic applications. Univ Johannes Gutenberg Thesis. Objective: Investigate the potential of using multivalent proteins as an integrative nanoplatform to target protein hallmarks in various diseases by forming supramolecular protein conjugates (SPC). Summary: The author employs an integrative and adaptable protein-based nanoplatform to combine bioactive

Chemical design of a supramolecular protein nanoplatform for therapeutic applications Read More »

Streptavidin-drug conjugates streamline optimization of antibody-based conditioning for hematopoietic stem cell transplantation

Yelamali AR, Chendamarai E, Ritchey JK, Rettig MP, DiPersio JF, Persaud SP (2024) Streptavidin-drug conjugates streamline optimization of antibody-based conditioning for hematopoietic stem cell transplantation. bioRxiv 2024.02.12.579199. doi: 10.1101/2024.02.12.579199 PMID: 38405731 Objective: Use biotinylated CD45.2 antibodies conjugated to Streptavidin to target hematopoietic stem cells (HSCs) for HSC transplantation. Summary: Hematopoietic stem cell transplantation offers a

Streptavidin-drug conjugates streamline optimization of antibody-based conditioning for hematopoietic stem cell transplantation Read More »

Non-genotoxic restoration of the hematolymphoid system in fanconi anemia

Chan YY, Ho PY, Swartzrock L, Rayburn M, Nofal R, Thongthip S, Weinberg KI, Czechowicz A (2023) Non-genotoxic restoration of the hematolymphoid system in fanconi anemia. Transplant Cell Ther 29(3):164.e1-164.e9. doi: 10.1016/j.jtct.2022.08.015 PMID: 35995393 Objective: Evaluate the efficacy of different CD117 mAb agents and immunosuppression on hematopoietic stem cell (HSC) depletion, and their ability to

Non-genotoxic restoration of the hematolymphoid system in fanconi anemia Read More »

Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of Simian immunodeficiency virus

Simpson J, Starke CE, Ortiz AM, Ransier A, Darko S, Llewellyn-Lacey S, Fennessey CM, Keele BF, Douek DC, Price DA, Brenchley JM (2024) Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of Simian immunodeficiency virus. JCI Insight e174168. doi: 10.1172/jci.insight.174168 PMID: 38885329 Objective: To investigate the role of gag epitope-specific CD8+ T cells

Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of Simian immunodeficiency virus Read More »

Search
Shopping Cart
Scroll to Top