Biotin-Z Internalization Kit (KIT-27-ZS) Read More »
Kfoury YS, Ji F, Jain E, Mazzola MC, Schiroli G, Papazian A, Mercier FE, Sykes DB, Kiem A, Randolph MA, Abdel-Wahab OI, Calvi LM, Sadreyev R, Scadden DT (2023) The bone marrow stroma in human myelodysplastic syndrome reveals alterations that regulate disease progression. Blood Adv bloodadvances.2022008268. doi: 10.1182/bloodadvances.2022008268 PMID: 37450380 Objective: Evaluate mesenchymal cell molecular
Screening targeting agents and their cell surface biomarkers for high specificity and rapid internalization via cell death and fluorescence. Ancheta L, Bouajram R, Lappi DA (2018) Society for Neuroscience, San Diego, CA. Abstract Some of the most recent successes in the treatment of cancers or research into passive immunotherapies for neurodegenerative diseases, employ the use
Konturek-Ciesla A, Dhapola P, Zhang Q, Säwén P, Wan H, Karlsson G, Bryder D (2023) Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. Cell Rep 42(4):112304. doi: 10.1016/j.celrep.2023.112304 PMID: 36961818 Objective: Using single-cell transcriptome and epitope profiling to study hematopoiesis and the effects from aging. Summary: The contribution from Hematopoietic
a tool for eliminating cells that express CD45.2 in mouse; targeted via the antibody to CD45.2, eliminated via saporin
Anti-CD45.2-SAP [IT-91, KIT-91] Read More »
Ancheta LR, Shramm PA, Bouajram R, Higgins D, Lappi DA (2023) Streptavidin-saporin: Converting biotinylated materials into targeted toxins. Toxins 15(3):181. doi: 10.3390/toxins15030181 PMID: 36977072 Summary: This manuscript describes the myriad of ways Streptavidin-ZAP is used and how this technology supports the scientific process of ‘Molecular Surgery’ and progress in research and drug development. Insights from
Streptavidin-saporin: Converting biotinylated materials into targeted toxins Read More »
Säwen P, Eldeeb M, Erlandsson E, Kristiansen TA, Laterza C, Kokaia Z, Karlsson G, Yuan J, Soneji S, Mandal PK, Rossi DJ, Bryder D (2018) Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging. Elife 7:e41258. doi: 10.7554/elife.41258 PMID: 30561324 Related Products: Streptavidin-ZAP (Cat. #IT-27)
Bloch JS, Sequeira JM, Ramírez AS, Quadros EV, Locher KP (2021) Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B12 uptake route. bioRxiv 2021.08.16.456495. doi: 10.1101/2021.08.16.456495 Related Products: Streptavidin-ZAP (Cat. #IT-27)
Q: I read on your website that, “There are two types of RIPs: type I, which are much less cytotoxic due to the lack of the B chain and type II, which are distinguished from type I RIPs by the presence of the B chain and their ability to enter cells on their own.” In
Which type of RIP is saporin? Read More »
Kim S, Shukla RK, Yu H, Baek A, Cressman SG, Golconda S, Lee GE, Choi H, Reneau JC, Wang Z, Huang CA, Liyanage NPM, Kim S (2022) CD3e-immunotoxin spares CD62Llo Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3ehi T cells. Front Immunol 13:1011190. doi: 10.3389/fimmu.2022.1011190 Objective: To use a new murine testing model