Biotin-Z Internalization Kit (KIT-27-ZS) Read More »
Kohls M (2006) Evaluate Potential Targeting Molecules. Nature Methods Summary: Targeted toxins — targeting agents conjugated to saporin — are widely used to eliminate specific cell populations both in vitro and in vivo. For these molecules to be effective, it is vital that the targeting component of the conjugate specifically binds the cells of interest.
Evaluate Potential Targeting Molecules. Read More »
Ancheta LR, Shramm PA, Bouajram R, Higgins D, Lappi DA (2023) Streptavidin-saporin: Converting biotinylated materials into targeted toxins. Toxins 15(3):181. doi: 10.3390/toxins15030181 Summary: This manuscript describes the myriad of ways Streptavidin-ZAP is used and how this technology supports the scientific process of ‘Molecular Surgery’ and progress in research and drug development. Insights from publications and
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Penna S, Villa A, Capo V (2021) Autosomal recessive osteopetrosis: mechanisms and treatments. Dis Model Mech 14(5):dmm048940. doi: 10.1242/dmm.048940 Summary: Autosomal recessive osteopetrosis (ARO) is a severe inherited bone disease characterized by defective osteoclast resorption or differentiation. Novel therapeutic approaches are needed for ARO patients. The authors review preclinical and proof-of-concept studies, such as gene
Autosomal recessive osteopetrosis: mechanisms and treatments Read More »
Contributed by Paul R. Hess, Adam S. Buntzman, Sabrina L. Murray, Ellen F. Young, and Jeffrey A. Frelinger;North Carolina State University College of Veterinary Medicine, Raleigh, NC;and University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, NC CD8+ T cells constitute important effectors of the adaptive immune response, functioning principally to remove infected cells
Facciabene A, Peng X, Hagemann IS, Balint K, Barchetti A, Wang L-P, Gimotty PA, Gilks CB, Lal P, Zhang L, Coukos G (2011) Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells. Nature 475:226-230. doi: 10.1038/nature10169 PMID: 21753853 Objective: To investigate whether a direct link between tumor hypoxia and tolerance occurs through the
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells Read More »
Konturek-Ciesla A, Dhapola P, Zhang Q, Säwén P, Wan H, Karlsson G, Bryder D (2023) Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. Cell Rep 42(4):112304. doi: 10.1016/j.celrep.2023.112304 PMID: 36961818 Objective: Using single-cell transcriptome and epitope profiling to study hematopoiesis and the effects from aging. Summary: The contribution from Hematopoietic
Wong JJW, Selbo PK (2021) Light-controlled elimination of PD-L1+ cells. J Photochem Photobiol B 225:112355. doi: 10.1016/j.jphotobiol.2021.112355 Objective: To investigate novel strategies that simultaneously target both tumor cells and immunosuppressive cells in the tumor microenvironment. The focus was on the evaluation in vitro of Anti-PD-L1-SAP combined with photochemical internalization (PCI) as a therapeutic strategy to
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IT-01: 192-IgG-SAP • Co-treatment with rivastigmine and idalopirdine reduces the propensity for falls in a rat model of falls in Parkinson’s disease. LID – 10.1007/s00213-018-5150-y [doi]. Koshy Cherian A et al. (2019). Psychopharmacol (Berl), [Epub ahead of print] Dose: Basal forebrain cholinergic neurons situated in the nucleus basalis and substantia innominata were targeted with
Q1 2019 Scientific Review Read More »
Hoffmann RM, Crescioli S, Thurston DE, Karagiannis SN (2018) Development and evaluation of T-Zap: a novel antibody-drug conjugate for the treatment of Her2 positive breast cancer. Cancer Res 78:LB-001. doi: 10.1158/1538-7445.AM2018-LB-001 PMID: 909090 Objective: Develop and Evaluate a novel ADC (T-Zap) for breast cancer. Summary: Binding to target cells of T-Zap was confirmed. Comparison of