Heck AJ (2023) Chemical design of a supramolecular protein nanoplatform for therapeutic applications. Univ Johannes Gutenberg Thesis.
Objective: Investigate the potential of using multivalent proteins as an integrative nanoplatform to target protein hallmarks in various diseases by forming supramolecular protein conjugates (SPC).
Summary: The author employs an integrative and adaptable protein-based nanoplatform to combine bioactive entities at the macromolecular level to design multivalent protein-conjugates for versatile therapeutic purposes. Multivalent protein-conjugates, a tetrameric protein with up to four ligand binding sites functions is used as a supramolecular “glue” utilizing avidin-biotin technology. The study investigates the assembly of diverse bioactive components into well organized multifunctional protein-conjugates, ultimately leading to the formation of supramolecular protein conjugates (SPC) that target protein signatures in a variety of diseases.
Usage: Streptavidin-ZAP with Anti-PSMA Antibody
Related Products: Streptavidin-ZAP (Cat. #IT-27)
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