The p75 neurotrophin receptor (p75NTR), also known as the low affinity nerve growth factor receptor, binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. It is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75 is expressed in various parts of the brain, notably in the basal forebrain by cholinergic neurons. The p75NTR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. Loss of these neurons is one of the hallmarks of Alzheimer’s disease.
ATS has created a suite of NGFR products for all of your research needs.
NGFR Products:
NGFR (192-IgG, p75) Mouse Monoclonal (Cat. #AB-N43) | Cy3-labeled (Cat. #AB-N43-FL3) | Alexa488-labeled (Cat. #AB-N43-FLA)
NGFR (mu p75) Rabbit Polyclonal (Cat. #AB-N01) | affinity-purified (Cat. #AB-N01AP) | biotin-labeled (Cat. #AB-N01AP-BT) | Cy3-labeled (Cat. #AB-N01AP-FL3) | Cy5-labeled (Cat. #AB-N01AP-FL5) | Alexa488-labeled (Cat. #AB-N01AP-FLA)
NGFR (ME20.4, p75) Mouse Monoclonal (Cat. #AB-N07) | biotin-labeled (Cat. #AB-N07-BT) | Alexa488-labeled (Cat. #AB-N07-FLA)
keywords: P75NTR, NGFR, Alzheimer’s Disease, dementia, CBF neurons, cholinergic forebrain, animal model, neuronal loss, low affinity nerve growth factor, neurotrophin receptors, mesenchyme, Anti-NGFR, Anti-Nerve Growth Factor, mup75, mu p75, brain, neuroscience