3D Reconstruction of the Neurovascular Unit Reveals Differential Loss of Cholinergic Innervation in the Cortex and Hippocampus of the Adult Mouse Brain. Nizari S, Carare RO, Romero IA, & Hawkes CA. (2019). Front Aging Neurosci, 11 (172). IT-16: mu p75-SAP Objective: To further characterize the effect of the loss of cholinergic innervation on the NVU […]
Latest Alzheimer’s Disease research using Targeting Tools Read More »
Latest research using 192-IgG-SAP to eliminate p75-positive neurons. Nitric Oxide Donor Molsidomine Promotes Retrieval of Object Recognition Memory in a Model of Cognitive Deficit Induced by 192 IgG-Saporin. (2019). Behav Brain Res, 366 108-117. Hernández-Melesio MA, Alcaraz-Zubeldia M, Jiménez-Capdeville ME, Martínez-Lazcano JC, Santoyo-Pérez ME, Quevedo-Corona L, Gerónimo-Olvera C, Sánchez-Mendoza A, Ríos C, & Pérez-Severiano F.
Targeting p75 LNGFr neurons Read More »
Stem cell research has great potential to understand, treat and cure diseases. By watching stem cells mature into cells in bones, heart muscle, nerves, and other organs and tissue, researchers can determine how diseases and conditions develop. Here are some recent publications that use ATS products to advance research involving stem cells. Figure Legend. Non-genotoxic conditioning for hematopoietic stem cell transplantation
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Glioblastoma, or glioblastoma multiforme (GBM), is a rare disease, with a global incidence of <10 per 100,000 people; the prognosis is very poor. Here are a couple of recent studies testing targeted saporin therapies. Integrin α10, a Novel Therapeutic Target in Glioblastoma, Regulates Cell Migration, Proliferation, and Survival. Munksgaard Thorén M, Chmielarska Masoumi K, Krona C,
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IT-01: 192-IgG-SAP • Co-treatment with rivastigmine and idalopirdine reduces the propensity for falls in a rat model of falls in Parkinson’s disease. LID – 10.1007/s00213-018-5150-y [doi]. Koshy Cherian A et al. (2019). Psychopharmacol (Berl), [Epub ahead of print] Dose: Basal forebrain cholinergic neurons situated in the nucleus basalis and substantia innominata were targeted with
Q1 2019 Scientific Review Read More »
Motor neuron diseases are a group of progressive neurological disorders that destroy motor neurons, the cells that control essential voluntary muscle activity such as speaking, walking, breathing, and swallowing. When there are disruptions in the signals between the lowest motor neurons and the muscle, the muscles do not work properly; the muscles gradually weaken and
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Advanced Targeting Systems and its Contract Service partner, CytoLogistics announce a Call For Proposals for research collaborations on: Receptor-mediated Delivery: New Targets Selected researchers will receive support for smaller scale or pilot research projects ($1,000 – $25,000) with the targeting tools and contract services needed for the identification and characterization of new cell-surface markers for
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Top Five Targeted Toxins 1. CTB-SAP (Cholera Toxin B-Saporin) (Cat. #IT-14) – targets cells expressing GM1 receptor 2. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase (DBH) 3. 192-IgG-SAP (192-Saporin) (Cat. #IT-01) – targets cells expressing rat p75NTR 4. Anti-ChAT-SAP (Cat. #IT-42) – targets cells expressing choline acetyltransferase 5. Nppb-SAP (Neuropeptide natriuretic polypeptide
Targeting Tools: Top Twenty of 2018 Read More »
Nilupaer Abudukeyoumu! Her poster was presented at the 2018 Society for Neuroscience meeting that was held in San Diego, CA: Impaired reach-to-grasp responses in mice depleted of striatal cholinergic interneurons Authors on the winning poster are pictured below L. to R.: Nilupaer Abudukeyoumu, Marianela Garcia-Munoz, Yoko Nakano, and Gordon W. Arbuthnott. Nilupaer Abudukeyoumu is a
2018 Poster of the Year Read More »