The ZAP Sulforhodamine B (SrB; Cat. #KIT-SrB-Z) Development kit contains all of the materials needed to introduce a quantitative staining assay to your lab. Preferred by the National Cancer Institute for high-throughput drug screening, SrB quantitatively stains cellular proteins in an accurate and reproducible manner. Refined and honed over years of use in testing Saporin-conjugate […]
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Targeted conjugates are widely used to escort payloads to specific cell populations in vitro and in vivo for both basic research and pharmaceutical development. Desirable traits of a Targeting Agent include high specificity and rapid internalization. The Targeting Agent can be an antibody, peptide, protein, or any other molecule that recognizes a cell- surface marker.
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ATS is pleased to announce Beta-release of a wide array of targeted toxins for use in eliminating specific cell types. This Beta-Testing Program will make new conjugates available to our customers sooner. Each of the Beta products will have: Saporin activity confirmed, Peptide sequences published/confirmed, and/or Antibody binding specificity published/confirmed. Beta Products have not been
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Screening large numbers of antibodies for the ability to internalize can be prohibitively expensive in both cost and time. The ZAP Antibody Internalization Kit contains all the components needed for three 96-well plates, or 288 tests. The ability to perform a diagnostic screen that is amenable to high-throughput methods, prior to direct conjugation of those
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Top Five Targeted Toxins #1. 192-IgG-SAP (192-Saporin) (Cat. #IT-01) targets cells expressing rat p75NTR #2. Anti-DBH-SAP (Cat. #IT-03) targets cells expressing rat dopamine beta-hydroxylase (DBH) #3. mu p75-SAP (Cat. #IT-16) targets cells expressing mouse p75NTR #4. IB4-SAP (Cat. #IT-10) targets cells expressing α-D-galactopyranoside residues #5. Mac-1-SAP mouse/human (Cat. #IT-06) targets cells expressing mouse / human
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Bombesin-SAP (Cat. #IT-40) Bombesin is a 14-amino-acid peptide found in frog-skin. The human equivalent, gastrin releasing peptide (GRP) has been detected in itch pathways and plays a role in eating behaviors. GRP regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation.
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Screening large numbers of antibodies for the ability to internalize can be prohibitively expensive in both cost and time. The ZAP Antibody Internalization Kit contains all the components needed for three 96-well plates, or 288 tests. The ability to perform a diagnostic screen that is amenable to high-throughput methods, prior to direct conjugation of those
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Isolectin B4 (IB4) is a tetrameric protein isolated from Griffonia simplicifolia seeds. Although one of its first uses was the agglutination of B-type red blood cells,[1] it has also been used extensively in the neurosciences because the alpha-galactosyl residues bound by IB4 are present on a variety of cell populations such as the non-peptidergic afferents
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Background of General Preparation and Components: Over the last few years, riding on the coattails of the established customer base for the ZAP line of secondary conjugates, Fab-ZAP has become the most popular ATS product group in the catalog. Combining species-specific monovalent secondary antibodies with the cytotoxic ribosome-inactivating protein, Saporin, the Fab-ZAP line of products
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Choline acetyltransferase (ChAT) catalyzes the synthesis of the neurotransmitter acetylcholine (ACh) from choline and acetyl-CoA in cholinergic neurons. ChAT serves as a specific marker for cholinergic neurons in both peripheral and central nervous systems. Dysfuntion of cholinergic neurons underlies aspects of clinical symptoms found in neurological and psychiatric disorders such as Alzheimer’s disease, Down and
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