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Contributed by Pierre-Henri Moreau, Brigitte Cosquer, Hélène Jeltsch, Jean-Christophe Cassel, Chantal MathisLaboratoire d’Imagerie et de Neurosciences Cognitives, UMR7191 CNRS,Equipe de Neurobiologie Cognitive et Comportementale, Université Louis Pasteur,IFR 37 de Neurosciences, GDR 2905 CNRS, 12 rue Goethe, 67000 Strasbourg, France The basal forebrain cholinergic neurons (BFCNs) are dramatically affected in several neurodegenerative diseases such as Alzheimer’s […]

Contributed by Kevin C.H. Pang, Xilu Jiao and Richard J. ServatiusNeuroscience Dept, New Jersey Med Sch – UMDNJ and VA Med Ctr – East Orange, NJ The medial septum and diagonal band of Broca (MSDB) provide a major afferent pathway to the hippocampus.[1] Cholinergic and GABAergic neurons are the main components of this pathway, but

Contributed by Robert M. Caudle, Ph.D.University of Florida College of Dentistry, Gainesville, FL 32610 A substantial amount of work with Advanced Targeting Systems’ substance P/saporin conjugate (SP-SAP, Cat. #IT-07) has demonstrated that neurokinin-1 (NK1) receptor-expressing neurons in the spinal cord and brain stem are necessary for the full expression of central sensitization following a peripheral

Contributed by Jeffrey T. Potts, Ph.D., Department of Biomedical Science, College of Veterinary Medicine, Dalton Cardiovascular Research Center, Columbia, MO 65211 The nucleus tractus solitarii (NTS) receives afferent input from visceral, somatic and cardiopulmonary structures and is the first central site for the processing of these sensory autonomic signals. Modulation of sensory neurotransmission has been well

Contributed by Neelima Chauhan, Dept Anesthes/Anat & Cell Bio, Univ Illinois-Chicago;J. Brown VA Med Ctr Chicago, Chicago, IL and winner of the 2006 SfN Poster Award for work using ATS products. Today’s Alzheimer’s disease (AD) research lacks a “complete” model that would represent both plaque and tangle pathology together with correlative memory deficits. The currently

This article is a summary of data presented in reference #1. Figures 1-4 are taken from that article. This work was funded by NS045520 and DK40498 to S. Ritter. Neuropeptide Y (NPY) conjugated to saporin (SAP), a ribosomal toxin, is a compound designed to selectively target and lesion NPY receptor-expressing cells. We conducted competitive binding

contributed by Jeffrey W. Allen, Ph.D.The author is currently a Senior Scientist in Emerging Therapies at Medtronic Neurological located in Minneapolis, MN.There is no association, financial or otherwise, between Medtronic, Inc. and Advanced Targeting Systems. Substance P-saporin (SP-SAP, Cat. #IT-07) is a targeted neurotoxin that selectively lesions cells containing the Neurokinin-1 (NK-1) receptor. Previous studies

Summary of contribution to “Recontres en toxinologie, 2005”by Ronald G. Wiley, Neurology Service (127) – VA TVHS, 1310 24th Avenue, South, Nashville, TN 37212 The use of targeted toxins in neuroscience research has evolved over the past twenty-plus years from original suicide transport lesions using ricin to highly selective neuron type-specific lesions made with immunotoxins,

Contributed by Josephine Lai, Wenjun Zhang, Hamid Badghisi, Victor J. Hruby(1) and Frank Porreca, Departments of Pharmacology and Chemistry(1), The University of Arizona, Tucson, AZ 85724. Cholecystokinin (CCK) is widely distributed in the central nervous system and the gastrointestinal tract. The 33-amino acid peptide contains a carboxyl terminal octapeptide sequence Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2 which confers the biological activity

Contributed by Kevin Pang and Heidi Smith, Bowling Green State University, Dept Psychology, Bowling Green, Ohio Hypocretin (or orexin) neurons are located in the hypothalamus and have been implicated in various functions including sleep, arousal and feeding. One area receiving dense hypocretin projections and expressing hypocretin-2 receptors (H-2r) is the medial septum (MS), an area