Targeting Topics

Q1 2019 Scientific Review

IT-01: 192-IgG-SAP     • Co-treatment with rivastigmine and idalopirdine reduces the propensity for falls in a rat model of falls in Parkinson’s disease. LID – 10.1007/s00213-018-5150-y [doi]. Koshy Cherian A et al. (2019). Psychopharmacol (Berl), [Epub ahead of print]  Dose: Basal forebrain cholinergic neurons situated in the nucleus basalis and substantia innominata were targeted with […]

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News from Science: Nppb in Itch / CRH antibody cross-reactivity

In 1997, Melanopsin was discovered by Dr. Ignacio Provencio as a novel opsin in the melanophores (light-sensitive skin cells) of the African clawed frog.1  Provencio and colleagues then found in 2000 that melanopsin is also present in mouse retina, specifically in ganglion cells, and that it mediates non-visual photoreceptive tasks.2   The figure below illustrates the specificity

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CTB-SAP and Targeted Ablation of dCSF-CNs

Targeted Ablation of Distal Cerebrospinal Fluid-Contacting Nucleus Alleviates Renal Fibrosis in Chronic Kidney Disease.  Qiu M, Li J, Tan L, Zhang M, Zhou G, Zeng T, Li A.  Front Physiol. https://doi.org/10.3389/fphys.2018.01640 CTB-SAP (Cat. #KIT-14) CTB-SAP causes ablation of any cell type expressing GM1, including preganglionic neurons, motoneurons, and astrocytes. Intrathecal injection of CTB-SAP results in

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NGF p75 antibody for brain research

Two more publications this week using an ATS exclusive antibody: NGFR (mu p75) Antibody (Cat. #AB-N01) Nicotinamide Mononucleotide Adenylyltransferase 2 maintains neuronal structural integrity through the maintenance of Golgi structure. Pottorf T, Mann A, Fross S, Mansel C, & Vohra BPS. (2018). Neurochem Intl Objective:  investigated the link between NMNAT2 loss, Golgi fragmentation and axon

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New Publications – Retinal Ganglion Cells and Cerebellar Purkinje Cells

Two publications out this week using ATS antibodies: Anti-Melanopsin (Cat. #AB-N38) and Anti-Metabotropic Glutamate Receptor 2 (mGluR2; Cat. #AB-N32) Sabbah S, Papendorp C, Koplas E, Beltoja M, Etebari C, Gunesch AN, Carrete L, Kim MT, Manoff G, Bhatia-Lin A, Zhao T, Schreck D, Dowling H, Briggman KL, Berson DM (2018) Synaptic circuits for irradiance coding

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Cytoplasmic Delivery of Aptamers

Screening Aptamers as Targeting Agents to deliver Payloads. Aptamers are small, synthetic, single-stranded nucleic acids that fold into unique secondary structures. Unlike peptides and monoclonal antibodies, they are essentially non-immunogenic even when administered in excess amounts. The publications below explain how biotinylated aptamers combined with Streptavidin-conjugated saporin (Streptavidin-ZAP) can be used to screen aptamers for

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