Author name: Kristen Hartman

Targeted ablation of mesenteric projecting sympathetic neurons reduces the hemodynamic response to pain in conscious spinal cord transected rats.

Lujan HL, Palani G, Peduzzi J, Dicarlo SE (2010) Targeted ablation of mesenteric projecting sympathetic neurons reduces the hemodynamic response to pain in conscious spinal cord transected rats. Am J Physiol Regul Integr Comp Physiol 298(5):R1358-1365. doi: 10.1152/ajpregu.00755.2009 Summary: Autonomic dysreflexia is a life-threatening hypertension as a result of a spinal cord injury above thoracic […]

Targeted ablation of mesenteric projecting sympathetic neurons reduces the hemodynamic response to pain in conscious spinal cord transected rats. Read More »

Unique contributions of distinct cholinergic projections to motor cortical plasticity and learning.

Conner JM, Kulczycki M, Tuszynski MH (2010) Unique contributions of distinct cholinergic projections to motor cortical plasticity and learning. Cereb Cortex 20(11):2739-2748. doi: 10.1093/cercor/bhq022 Summary: This work mapped the basal cholinergic forebrain system associations with skilled motor learning and motor function recovery after cortical injury. Rats were lesioned with 192-IgG-SAP (Cat. #IT-01). The animals received

Unique contributions of distinct cholinergic projections to motor cortical plasticity and learning. Read More »

Photochemical internalization (PCI): a technology for drug delivery.

Berg K, Weyergang A, Prasmickaite L, Bonsted A, Hogset A, Strand MT, Wagner E, Selbo PK (2010) Photochemical internalization (PCI): a technology for drug delivery. (eds. Gomer C). In: Photodynamic Therapy. Methods in Molecular Biology. 635:133-145. Humana Press, Totowa, NJ. doi: 10.1007/978-1-60761-697-9_10 Summary: This review discusses photochemical internalization (PCI), which is a method used to

Photochemical internalization (PCI): a technology for drug delivery. Read More »

The brainstem noradrenergic systems in stress, anxiety, and depression.

Itoi K, Sugimoto N (2010) The brainstem noradrenergic systems in stress, anxiety, and depression. J Neuroendocrinol 22(5):355-361. doi: 10.1111/j.1365-2826.2010.01988.x Summary: In this review the authors examine the relationship between the central noradrenergic system, fear/anxiety states, and depression. The use of anti-DBH-SAP (Cat. #IT-03) to investigate the function of the noradrenergic system in these paradigms is

The brainstem noradrenergic systems in stress, anxiety, and depression. Read More »

Targeted ablation of cardiac sympathetic neurons reduces the susceptibility to ischemia-induced sustained ventricular tachycardia in conscious rats.

Lujan HL, Palani G, Zhang L, Dicarlo SE (2010) Targeted ablation of cardiac sympathetic neurons reduces the susceptibility to ischemia-induced sustained ventricular tachycardia in conscious rats. Am J Physiol Heart Circ Physiol 298:H1330-H1339. doi: 10.1152/ajpheart.00955.2009 Summary: It has been shown that reduction of cardiac sympathetic activity protects against ventricular tachy-arrhythmias, which are the leading cause

Targeted ablation of cardiac sympathetic neurons reduces the susceptibility to ischemia-induced sustained ventricular tachycardia in conscious rats. Read More »

Transplant of GABAergic precursors restores hippocampal inhibitory function in a mouse model of seizure susceptibility.

Zipancic I, Calcagnotto ME, Piquer-Gil M, Mello LE, Alvarez-Dolado M (2010) Transplant of GABAergic precursors restores hippocampal inhibitory function in a mouse model of seizure susceptibility. Cell Transplant 19(5):549-564. doi: 10.3727/096368910X491383 Summary: Although medial ganglionic eminence-derived cells can be grafted into the neonatal brain and become functionally mature GABAergic neurons it is not clear whether

Transplant of GABAergic precursors restores hippocampal inhibitory function in a mouse model of seizure susceptibility. Read More »

Recent progress in research on ribosome inactivating proteins.

Ng TB, Wong JH, Wang H (2010) Recent progress in research on ribosome inactivating proteins. Curr Protein Pept Sci 11(1):37-53. doi: 10.2174/138920310790274662 Summary: This review discusses recent literature on ribosome inactivating proteins including the use of saporin-based conjugates in neuroscience and cancer research. Brief descriptions of research done using 192-IgG-SAP (Cat. #IT-01), OX7-SAP (Cat. #IT-02),

Recent progress in research on ribosome inactivating proteins. Read More »

The cerebellum harbors a circadian oscillator involved in food anticipation.

Mendoza J, Pevet P, Felder-Schmittbuhl MP, Bailly Y, Challet E (2010) The cerebellum harbors a circadian oscillator involved in food anticipation. J Neurosci 30:1894-1904. doi: 10.1523/JNEUROSCI.5855-09.2010 Summary: The authors report on a circadian oscillator in the cerebellum that is sensitive to feeding cues. Mice received intracerebroventricular injections of 0.12, 0.25, or 0.50 µg of OX7-SAP

The cerebellum harbors a circadian oscillator involved in food anticipation. Read More »

Enrichment of xenograft-competent genetically modified pig cells using a targeted toxin, isolectin BS-I-B4 conjugate.

Akasaka E, Watanabe S, Himaki T, Ohtsuka M, Yoshida M, Miyoshi K, Sato M (2010) Enrichment of xenograft-competent genetically modified pig cells using a targeted toxin, isolectin BS-I-B4 conjugate. Xenotransplantation 17:81-89. doi: 10.1111/j.1399-3089.2010.00568.x Summary: Genetically modified pigs lacking the gala1-3gal epitope may be suitable for production of organs that could be transplanted to humans. The

Enrichment of xenograft-competent genetically modified pig cells using a targeted toxin, isolectin BS-I-B4 conjugate. Read More »

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