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Substance P modulation of hypoglossal motoneuron excitability during development: changing balance between conductances.

Adachi T, Huxtable AG, Fang X, Funk GD (2010) Substance P modulation of hypoglossal motoneuron excitability during development: changing balance between conductances. J Neurophysiol 104(2):854-872. doi: 10.1152/jn.00016.2010

Summary: This work examined how neuromuscular networks that are immature, but functional, at birth move through development while remaining operational. The authors focused on hypoglossal motoneurons involved in behaviors such as swallowing, suckling, and breathing. Immunohistochemistry was performed using an anti-NK-1 receptor antibody (Cat. #AB-N04). The data show that although NK-1 receptor density decreases as the animal matures, substance P (the NK-1 receptor ligand) remains an important part of these networks.

Related Products: Antibody to NK-1 Receptor (Cat. #AB-N04)