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  4. Splanchnic sympathectomy prevents translocation and spreading of E coli but not S aureus in liver cirrhosis.

Splanchnic sympathectomy prevents translocation and spreading of E coli but not S aureus in liver cirrhosis.

Worlicek M, Knebel K, Linde HJ, Moleda L, Scholmerich J, Straub RH, Wiest R (2010) Splanchnic sympathectomy prevents translocation and spreading of E coli but not S aureus in liver cirrhosis. Gut 59(8):1127-1134. doi: 10.1136/gut.2009.185413

Summary: Advanced cirrhosis activates the sympathetic nervous system. This work investigates the role of the sympathetic nervous system (SNS) in spontaneous bacterial peritonitis – which is mainly caused by translocation of enteric Gram-negative bacteria. Rats received 15 µg intraperitoneal injections of anti-DBH-SAP (Cat. #IT-03). Lesioned animals displayed increased susceptibility to bacterial translocation and infection with E. coli but not S. aureus. This suggests the SNS plays an important role in the immune response to Gram-negative bacteria.

Related Products: Anti-DBH-SAP (Cat. #IT-03)