Hummel M, Cummons T, Lu P, Mark L, Harrison JE, Kennedy JD, Whiteside GT (2010) Pain is a salient “stressor” that is mediated by corticotropin-releasing factor-1 receptors. Neuropharmacology 59(3):160-166. doi: 10.1016/j.neuropharm.2010.05.001
Summary: Given that corticotrophin-releasing factor (CRF) plays a major role in the response to stress, the authors investigated the role CRF-1 receptors may play in the perception of pain. Both rats and mice received 10µl intrathecal injections of 10 µM CRF-SAP (Cat. #IT-13) following a spinal nerve ligation. Administration of CRF-SAP attenuated tactile hypersensitivity, indicating that CRF-1 receptors are involved in pain perception.
Related Products: CRF-SAP (Cat. #IT-13)