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  4. Damage of GABAergic neurons in the medial septum impairs spatial working memory and extinction of active avoidance: Effects on proactive interference.

Damage of GABAergic neurons in the medial septum impairs spatial working memory and extinction of active avoidance: Effects on proactive interference.

Pang KCH, Jiao X, Sinha S, Beck KD, Servatius RJ (2011) Damage of GABAergic neurons in the medial septum impairs spatial working memory and extinction of active avoidance: Effects on proactive interference. Hippocampus 21(8):835-846. doi: 10.1002/hipo.20799

Summary: Recent work implicates the medial septum (MS) and diagonal band (DB) in the control of proactive interference — forgetting older information when learning new information. Rats received GAT1-SAP (Cat. #IT-32) injections into the MS and the DB (162.5 ng and 130 ng respectively, the DB injections were bilateral). The results parallel other studies using different toxins, reinforcing the indications that GABAergic MSDB neurons are an integral part of proactive interference control.

Related Products: 192-IgG-SAP (Cat. #IT-01), GAT1-SAP (Cat. #IT-32)