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Medial septal cholinergic neurons are necessary for context-place memory but not episodic-like memory.

Easton A, Fitchett AE, Eacott MJ, Baxter MG (2011) Medial septal cholinergic neurons are necessary for context-place memory but not episodic-like memory. Hippocampus 21(9):1021-1027. doi: 10.1002/hipo.20814

Summary: Although it is clear that neurodegenerative diseases cause memory impairment, it is uncertain to what extent cholinergic deficits cause this loss of function. The authors administered a total of 150 ng of 192-IgG-SAP (Cat. #IT-01) into the medial septum and vertical limb of the diagonal band of Broca in rats. The lesioned animals were then tested in a rodent model for human episodic memory. The rats performed well on these tests, but struggled with tests that tested the association of places with context. The results suggest that hippocampal spatial representations might not be essential for episodic memory function.

Related Products: 192-IgG-SAP (Cat. #IT-01)