Author name: Kristen Hartman

Selective formation of covalent protein heterodimers with an unnatural amino acid.

Hutchins BM, Kazane SA, Staflin K, Forsyth JS, Felding-Habermann B, Smider VV, Schultz PG (2011) Selective formation of covalent protein heterodimers with an unnatural amino acid. Chem Biol 18(3):299-303. doi: 10.1016/j.chembiol.2011.01.006 PMID: 21439474 Summary: This work demonstrates the creation of a variety of constructs containing specific defined conjugation sites. One use for these molecules is […]

Selective formation of covalent protein heterodimers with an unnatural amino acid. Read More »

Sezary syndrome cells overexpress syndecan-4 bearing distinct heparan sulfate moieties that suppress T-cell activation by binding DC-HIL and trapping TGF-beta on the cell surface.

Chung JS, Shiue LH, Duvic M, Pandya A, Cruz PDJ, Ariizumi K (2011) Sezary syndrome cells overexpress syndecan-4 bearing distinct heparan sulfate moieties that suppress T-cell activation by binding DC-HIL and trapping TGF-beta on the cell surface. Blood 117(12):3382-3390. doi: 10.1182/blood-2010-08-302034 Summary: Syndecan-4 (SD-4) is a transmembrane heparan sulfate proteoglycan. The Sézary syndrome (SS) subset

Sezary syndrome cells overexpress syndecan-4 bearing distinct heparan sulfate moieties that suppress T-cell activation by binding DC-HIL and trapping TGF-beta on the cell surface. Read More »

Molsidomine modulates the cNOS activity in an experimental model of cholinergic damage induced by 192-IgG saporin.

Hernandez-Melesio MA, Gonzalez-Esquivel D, Ortiz-Plata A, Sanchez-Mendoza A, Sanchez-Garcia A, Alcaraz-Zubeldia M, Rios C, Perez-Severiano F (2011) Molsidomine modulates the cNOS activity in an experimental model of cholinergic damage induced by 192-IgG saporin. Neurosci Lett 491(2):133-137. doi: 10.1016/j.neulet.2011.01.023 Summary: Nitric oxide (NO) is required for the survival of cholinergic neurons in the basal forebrain. Delivery

Molsidomine modulates the cNOS activity in an experimental model of cholinergic damage induced by 192-IgG saporin. Read More »

Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke.

Heldmann U, Mine Y, Kokaia Z, Ekdahl CT, Lindvall O (2011) Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke. Exp Neurol 229(2):391-398. doi: 10.1016/j.expneurol.2011.03.005 Summary: One result of ischemic stroke is migration of newly formed neuroblasts into the injured area from the subventricular zone (SVZ). The

Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke. Read More »

The effects of intrathecal and systemic gabapentin on spinal substance P release.

Takasusuki T, Yaksh TL (2011) The effects of intrathecal and systemic gabapentin on spinal substance P release. Anesth Analg 112(4):971-976. doi: 10.1213/ANE.0b013e31820f2a16 PMID: 21385982 Summary: Intrathecal or systemically-administered gabapentin is an antihyperalgesic. Given that gabapentin binds a voltage-sensitive calcium channel and that some of these channels regulate substance P (SP) release, the authors investigated whether

The effects of intrathecal and systemic gabapentin on spinal substance P release. Read More »

Orexin-B-saporin lesions in the lateral hypothalamus enhance photic masking of rapid eye movement sleep in the albino rat.

Ocampo-Garces A, Ibanez F, Perdomo G, Torrealba F (2011) Orexin-B-saporin lesions in the lateral hypothalamus enhance photic masking of rapid eye movement sleep in the albino rat. J Sleep Res 20:3-11. doi: 10.1111/j.1365-2869.2010.00864.x Summary: Photic masking occurs when photic input to the retina interferes with REM sleep. Rats that received 200 ng of orexin-SAP (Cat.

Orexin-B-saporin lesions in the lateral hypothalamus enhance photic masking of rapid eye movement sleep in the albino rat. Read More »

Human monoclonal antibodies to Sialyl-Lewisa (CA19.9) with potent CDC, ADCC, and antitumor activity.

Sawada R, Sun SM, Wu X, Hong F, Ragupathi G, Livingston PO, Scholz WW (2011) Human monoclonal antibodies to Sialyl-Lewisa (CA19.9) with potent CDC, ADCC, and antitumor activity. Clin Cancer Res 17(5):1024-1032. doi: 10.1158/1078-0432.CCR-10-2640 Summary: In this work the authors investigated the use of a carbohydrate antigen, sialyl-Lewisa (CA19.9), as a target for cancer therapeutics.

Human monoclonal antibodies to Sialyl-Lewisa (CA19.9) with potent CDC, ADCC, and antitumor activity. Read More »

TrkB (Tropomyosin-related kinase B) controls the assembly and maintenance of GABAergic synapses in the cerebellar cortex

Chen AI, Nguyen CN, Copenhagen DR, Badurek S, Minichiello L, Ranscht B, Reichardt LF (2011) TrkB (Tropomyosin-related kinase B) controls the assembly and maintenance of GABAergic synapses in the cerebellar cortex. J Neurosci 31(8):2769-2780. doi: 10.1523/JNEUROSCI.4991-10.2011 PMID: 21414899 Summary: In this work the authors investigated the role of TrkB in GABAergic inhibitory synapses in the

TrkB (Tropomyosin-related kinase B) controls the assembly and maintenance of GABAergic synapses in the cerebellar cortex Read More »

Gene regulation in the rat prefrontal cortex after learning with or without cholinergic insult.

Paban V, Chambon C, Farioli F, Alescio-Lautier B (2011) Gene regulation in the rat prefrontal cortex after learning with or without cholinergic insult. Neurobiol Learn Mem 95(4):441-452. doi: 10.1016/j.nlm.2011.02.005 Summary: Microarray technology was used to screen gene expression in a model of attention and memory deficit. Rats received bilateral injections of 192-IgG-SAP (Cat. #IT-01) into

Gene regulation in the rat prefrontal cortex after learning with or without cholinergic insult. Read More »

The effects of neonatal forebrain cholinergic lesion on adult hippocampal neurogenesis.

Rennie K, Frechette M, Pappas BA (2011) The effects of neonatal forebrain cholinergic lesion on adult hippocampal neurogenesis. Brain Res 1373(10):79-90. doi: 10.1016/j.brainres.2010.11.091 Summary: Intraventricular injections of 192-IgG-SAP (Cat. #IT-01) have been shown to reduce the number of cells expressing a marker for immature neuroblasts in the dentate gyrus, as well as possibly impairing the

The effects of neonatal forebrain cholinergic lesion on adult hippocampal neurogenesis. Read More »

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