Author name: Kristen Hartman

Krx-0501 reduces cognitive deficits in a saporin mouse model of Alzheimer’s disease

Lowrance SA, Matchynski JJ, Rossignol J, Dekorver N, Fink K, Salibi P, Dunbar GL (2010) Krx-0501 reduces cognitive deficits in a saporin mouse model of Alzheimer’s disease. Neuroscience 2010 Abstracts 856.8/I14. Society for Neuroscience, San Diego, CA. Summary: Alzheimer’s disease (AD) is a progressive neurodegenerative disease marked by memory loss and dysfunction of cholinergic neurons. […]

Krx-0501 reduces cognitive deficits in a saporin mouse model of Alzheimer’s disease Read More »

Targeting inhibitory neurons in the superficial dorsal horn: Somatostatin-saporin

Chatterjee K, Lemons LL, Wiley RG (2010) Targeting inhibitory neurons in the superficial dorsal horn: Somatostatin-saporin. Neuroscience 2010 Abstracts 585.1/XX15. Society for Neuroscience, San Diego, CA. Summary: Intrathecal injection of somatostatin (SST), or the long-acting congener, octreotide, have been reported analgesic in humans with intractable pain. The principal SST receptor, sst2a, is expressed by GABAergic

Targeting inhibitory neurons in the superficial dorsal horn: Somatostatin-saporin Read More »

Targeting inhibitory neurons in the superficial dorsal horn: Neurotensin-saporin (NTS-sap) and neurotensin-cholera toxin A subunit (NTS-CTA)

Wiley RG, Lemons LL, Chatterjee K (2010) Targeting inhibitory neurons in the superficial dorsal horn: Neurotensin-saporin (NTS-sap) and neurotensin-cholera toxin A subunit (NTS-CTA). Neuroscience 2010 Abstracts 585.2/XX16. Society for Neuroscience, San Diego, CA. Summary: Neurotensin (NTS) and high affinity neurotensin receptors (NTSR-1) are found in the superficial dorsal horn, primarily lamina II. Intrathecal NTS has

Targeting inhibitory neurons in the superficial dorsal horn: Neurotensin-saporin (NTS-sap) and neurotensin-cholera toxin A subunit (NTS-CTA) Read More »

Neuropeptide receptor co-expression in superficial dorsal horn: Effects of galanin-saporin, neuropeptide y-saporin and dermorphin-saporin

Lemons LL, Chatterjee K, Wiley RG (2010) Neuropeptide receptor co-expression in superficial dorsal horn: Effects of galanin-saporin, neuropeptide y-saporin and dermorphin-saporin. Neuroscience 2010 Abstracts 585.5/XX19. Society for Neuroscience, San Diego, CA. Summary: We have previously shown that the role of specific neurons in behavioral processes can be fruitfully studied using targeted toxins. Toxins composed of

Neuropeptide receptor co-expression in superficial dorsal horn: Effects of galanin-saporin, neuropeptide y-saporin and dermorphin-saporin Read More »

Damage of GABAergic neurons in the medial septum-diagonal band (MSDB) reduces behaviorally-activated hippocampal acetylcholine efflux and impairs spatial working memory

Roland JJ, Janke KL, Savage LM, Servatius RJ, Pang KCH (2010) Damage of GABAergic neurons in the medial septum-diagonal band (MSDB) reduces behaviorally-activated hippocampal acetylcholine efflux and impairs spatial working memory. Neuroscience 2010 Abstracts 611.13/MMM64. Society for Neuroscience, San Diego, CA. Summary: The septohippocampal pathway is mostly composed of cholinergic and GABAergic projections and has

Damage of GABAergic neurons in the medial septum-diagonal band (MSDB) reduces behaviorally-activated hippocampal acetylcholine efflux and impairs spatial working memory Read More »

Effects of basal forebrain cholinergic lesions and estradiol on relative levels of estrogen receptor mRNAs in the rat forebrain

Hammond R, Shinde A, Gibbs RB (2010) Effects of basal forebrain cholinergic lesions and estradiol on relative levels of estrogen receptor mRNAs in the rat forebrain. Neuroscience 2010 Abstracts 611.16/MMM67. Society for Neuroscience, San Diego, CA. Summary: Beneficial effects of estradiol on cognitive performance are lost in response to cholinergic denervation of the hippocampus and

Effects of basal forebrain cholinergic lesions and estradiol on relative levels of estrogen receptor mRNAs in the rat forebrain Read More »

The arcuate nucleus of the hypothalamus controls the circadian distribution of sleep and feeding

Wiater MF, Mukherjee S, Dinh TT, Rooney E, Li A-J, Simasko SM, Ritter S (2010) The arcuate nucleus of the hypothalamus controls the circadian distribution of sleep and feeding. Neuroscience 2010 Abstracts 648.16/H17. Society for Neuroscience, San Diego, CA. Summary: Integration of daily sleep and feeding rhythms is incompletely understood. We examined the role of

The arcuate nucleus of the hypothalamus controls the circadian distribution of sleep and feeding Read More »

NK-1 Receptors in the RVM: Involvement in hyperalgesia produced by naloxone but not in morphine analgesia

Khasabov SG, Fliss PM, Rao AS, Simone DA (2010) NK-1 Receptors in the RVM: Involvement in hyperalgesia produced by naloxone but not in morphine analgesia. Neuroscience 2010 Abstracts 678.15/QQ2. Society for Neuroscience, San Diego, CA. Summary: The rostral ventromedial medulla (RVM) is a crucial supraspinal site for opioid analgesia. Descending modulation of nociceptive transmission by

NK-1 Receptors in the RVM: Involvement in hyperalgesia produced by naloxone but not in morphine analgesia Read More »

Morphine-induced pain hypersensitivity, but not opioid tolerance, depends on microglia-mediated alteration of Cl- homeostasis in spinal dorsal horn

Ferrini F, Mattioli TAM, Lorenzo L-E, Godin A, Wiseman PW, Ribeiro-Da-Silva A, Cahill CM, Milne B, De Koninck Y (2010) Morphine-induced pain hypersensitivity, but not opioid tolerance, depends on microglia-mediated alteration of Cl- homeostasis in spinal dorsal horn. Neuroscience 2010 Abstracts 678.9/PP14. Society for Neuroscience, San Diego, CA. Summary: Prolonged morphine exposure leads to a

Morphine-induced pain hypersensitivity, but not opioid tolerance, depends on microglia-mediated alteration of Cl- homeostasis in spinal dorsal horn Read More »

Patterning of somatosympathetic reflexes: Identification of distinct bulbospinal sympathoexcitatory RVLM projections by conduction velocity and catecholamine phenotype

Burke PG, Neale J, Korim WS, Mcmullan S, Pilowsky PM, Goodchild AK (2010) Patterning of somatosympathetic reflexes: Identification of distinct bulbospinal sympathoexcitatory RVLM projections by conduction velocity and catecholamine phenotype. Neuroscience 2010 Abstracts 694.11/HHH34. Society for Neuroscience, San Diego, CA. Summary: The aim of this study was to examine the somatosympathetic reflex (SSR) response of

Patterning of somatosympathetic reflexes: Identification of distinct bulbospinal sympathoexcitatory RVLM projections by conduction velocity and catecholamine phenotype Read More »

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