1. Home
  2. Knowledge Base
  3. References
  4. The effects of intrathecal and systemic gabapentin on spinal substance P release.

The effects of intrathecal and systemic gabapentin on spinal substance P release.

Takasusuki T, Yaksh TL (2011) The effects of intrathecal and systemic gabapentin on spinal substance P release. Anesth Analg 112(4):971-976. doi: 10.1213/ANE.0b013e31820f2a16

Summary: Intrathecal or systemically-administered gabapentin is an antihyperalgesic. Given that gabapentin binds a voltage-sensitive calcium channel and that some of these channels regulate substance P (SP) release, the authors investigated whether gabapentin affects SP levels. Immunohistochemistry was done in rats following a gabapentin/formalin pain model. A neurokinin-1 receptor antibody (Cat. #AB-N04) was used to quantitate NK1r, and therefore assess SP activity. It was found that both spinal and systemic gabapentin inhibit SP release from small, primary afferents.

Related Products: Antibody to NK-1 Receptor (Cat. #AB-N04)