Rennie K, Frechette M, Pappas BA (2011) The effects of neonatal forebrain cholinergic lesion on adult hippocampal neurogenesis. Brain Res 1373(10):79-90. doi: 10.1016/j.brainres.2010.11.091
Summary: Intraventricular injections of 192-IgG-SAP (Cat. #IT-01) have been shown to reduce the number of cells expressing a marker for immature neuroblasts in the dentate gyrus, as well as possibly impairing the response to environmental enrichment. This study looked to expand on those observations. 300 ng of 192-IgG-SAP was infused into each ventricle of post-natal day 7 rats. The data suggest that the lesion accelerates the death of newborn cells, but does not affect survival rate or phenotypic differentiation.
Related Products: 192-IgG-SAP (Cat. #IT-01)