Basic fibroblast growth factor (FGF-2) is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration […]
Targeting Tools: FGF-2 Human Recombinant Read More »
Leptin is a 16-kDa peptide hormone secreted from white adipocytes and implicated in the regulation of food intake and energy balance. It provides the key afferent signal from fat cells in the feedback system that controls body fat stores. Leptin Human Recombinant, Cat. #PRP-228CYTavailable in these sizes: 200 micrograms, 1 milligram, and 5 milligrams Related
Targeting Tools: Leptin Human Recombinant Read More »
Granulocyte Macrophage Colony Stimulating Factor (GM CSF) is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with
Targeting Tools: GM-CSF Human Recombinant Read More »
Growth Hormone (GH) is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved
Targeting Tools: Growth Hormone Human Recombinant Read More »
Q: Using Mab-ZAP (Cat. #IT-04) in a cytotoxicity assay, I obtained a nice dose-response curve up to around 10-9 M of antibody and then lost progressively the toxic effect of Mab-ZAP. What should I do to improve in my assay? A: If the highest dose for which you got a good response was 10 nM
Assay Parameters for Mab-ZAP Read More »
Sorkin LS, Choi JI, Koehrn FJ (2011) Featured Article: Carrageenan evoked P-Akt in deep dorsal horn neurons is prevented by loss of neurokinin1 positive neurons in superficial dorsal horn. Targeting Trends 12(2) Related Products: SSP-SAP (Cat. #IT-11) Read the featured article in Targeting Trends. See Also: Sorkin LS et al. Carageenan evoked P-Akt in deep
by Leonardo R. Ancheta and Douglas A. Lappi, American Association of Cancer Research abstract #5218 Basigin-2 (EMMPRIN) is a marker for prognosis of several tumor types. With the identification of the internalization of basigin-2 in response to antibody binding, we now further explore the possibility of its use as a dynamic portal of entry for
Contributed by L.S. Sorkin, J.-I. Choi, and F.J. Koehrn, Univ. California San Diego, La Jolla, CA Paw inflammation with carrageenan elicits phosphorylation of Akt in spinal cord neurons with an unusual time course (Choi et al., 2010). Activation of Akt is seen first in neurons of the superficial dorsal horn and in α-motor neurons, followed
Fuller P, Sherman D, Pedersen NP, Saper CB, Lu J (2011) Reassessment of the structural basis of the ascending arousal system. J Comp Neurol 519(5):933-956. doi: 10.1002/cne.22559 Summary: Traditional thought has been that electroencephalogram activity is mainly generated by the thalamo-cortical system. In this work the authors investigated the effects of basal forebrain lesions on
Reassessment of the structural basis of the ascending arousal system. Read More »
Laplante F, Lappi DA, Sullivan RM (2011) Cholinergic depletion in the nucleus accumbens: Effects on amphetamine response and sensorimotor gating. Prog Neuropsychopharmacol Biol Psychiatry 35(2):501-509. doi: 10.1016/j.pnpbp.2010.12.005 Summary: Disruption of dopamine and acetylcholine balance in the striatum may play a role in conditions such as Parkinson’s and schizophrenia. In this work the authors lesioned cholinergic