1. Home
  2. Knowledge Base
  3. References
  4. Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke.

Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke.

Heldmann U, Mine Y, Kokaia Z, Ekdahl CT, Lindvall O (2011) Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke. Exp Neurol 229(2):391-398. doi: 10.1016/j.expneurol.2011.03.005

Summary: One result of ischemic stroke is migration of newly formed neuroblasts into the injured area from the subventricular zone (SVZ). The authors investigated the role of microglia, which also accumulate in the SVZ after stroke, in this process. Rats received 5-µg or 10-µg intracerebroventricular injections of Mac-1-SAP (Cat. #IT-33) with varying schedules as to injection and sacrifice. The data indicate that the presence of microglia after stroke does not affect the number or migration of neuroblasts from the SVZ.

Related Products: Mac-1-SAP rat (Cat. #IT-33)