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TrkB (Tropomyosin-related kinase B) controls the assembly and maintenance of GABAergic synapses in the cerebellar cortex

Chen AI, Nguyen CN, Copenhagen DR, Badurek S, Minichiello L, Ranscht B, Reichardt LF (2011) TrkB (Tropomyosin-related kinase B) controls the assembly and maintenance of GABAergic synapses in the cerebellar cortex. J Neurosci 31(8):2769-2780. doi: 10.1523/JNEUROSCI.4991-10.2011

Summary: In this work the authors investigated the role of TrkB in GABAergic inhibitory synapses in the mouse cerebellar cortex. Using a variety of techniques, including immunohistochemistry utilizing an mGluR2 antibody (Cat. #AB-N32), it was shown that TrkB is required for both assembly and maintenance of these synapses. The primary role of TrkB appears to be regulating the localization of synaptic constituents.

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