Author name: Kristen Hartman

Selective C1 lesioning slightly decreases angiotensin II type I receptor expression in the rat rostral ventrolateral medulla (RVLM).

Bourassa E, Stedenfeld K, Sved A, Speth R (2015) Selective C1 lesioning slightly decreases angiotensin II type I receptor expression in the rat rostral ventrolateral medulla (RVLM). Neurochem Res 40:2113-2120. doi: 10.1007/s11064-015-1649-3 Summary: Exogenous angiotensin II administered to the RVLM produces a significant pressor response that can be countered by angiotensin II type I receptor […]

Selective C1 lesioning slightly decreases angiotensin II type I receptor expression in the rat rostral ventrolateral medulla (RVLM). Read More »

Cover Article: SP-SAP Human Clinical Trial for Cancer Pain – An Anesthesiologist’s Point of View

News Article /

by Carl Noe, M.D., Anesthesiology & Pain Management, UT Southwestern Medical Center, Dallas, TX; and Eugene McDermott Center for Pain Management, Dallas, Texas Dr. Noe is the Principal Investigator in the ongoing trial of SP-SAP Intrathecal SP-SAP (Substance P attached to the ribosome-inactivating protein, saporin) has been studied in a Phase 1 clinical trial of

Cover Article: SP-SAP Human Clinical Trial for Cancer Pain – An Anesthesiologist’s Point of View Read More »

Retrograde transport is not required for cytosolic translocation of the B-subunit of Shiga toxin.

Garcia-Castillo M, Tran T, Bobard A, Renard H, Rathjen S, Dransart E, Stechmann B, Lamaze C, Lord M, Cintrat J, Enninga J, Tartour E, Johannes L (2015) Retrograde transport is not required for cytosolic translocation of the B-subunit of Shiga toxin. J Cell Sci 128:2373-2387. doi: 10.1242/jcs.169383 Summary: Bacterial and plant toxins rely on various

Retrograde transport is not required for cytosolic translocation of the B-subunit of Shiga toxin. Read More »

Monoclonal antibodies targeting LecLex-related glycans with potent antitumor activity.

Chua J, Vankemmelbeke M, McIntosh R, Clarke P, Moss R, Parsons T, Spendlove I, Zaitoun A, Madhusudan S, Durrant L (2015) Monoclonal antibodies targeting LecLex-related glycans with potent antitumor activity. Clin Cancer Res 21:2963-2974. doi: 10.1158/1078-0432.CCR-14-3030 Summary: In this work the authors characterized two monoclonal antibodies that target glycans containing Lewis carbohydrate antigens. One of

Monoclonal antibodies targeting LecLex-related glycans with potent antitumor activity. Read More »

proBDNF and p75NTR control excitability and persistent firing of cortical pyramidal neurons.

Gibon J, Buckley S, Unsain N, Kaartinen V, Séguéla P, Barker P (2015) proBDNF and p75NTR control excitability and persistent firing of cortical pyramidal neurons. J Neurosci 35:9741-9753. doi: 10.1523/JNEUROSCI.4655-14.2015 PMID: 26134656 Summary: Principal neurons in the entorhinal cortex (EC) display persistent firing (PF) during working-memory tasks. Much of the communication between the hippocampus and

proBDNF and p75NTR control excitability and persistent firing of cortical pyramidal neurons. Read More »

Inflammatory macrophages promotes development of diabetic encephalopathy.

Wang B, Miao Y, Zhao Z, Zhong Y (2015) Inflammatory macrophages promotes development of diabetic encephalopathy. Cell Physiol Biochem 36:1142-1150. doi: 10.1159/000430285 Summary: Diabetes can cause neuroinflammation leading to dementia. Diabetes was induced in mice by injection of streptozotocin (STZ). In order to investigate the role of inflammatory macrophages in the development of diabetic encephalopathy,

Inflammatory macrophages promotes development of diabetic encephalopathy. Read More »

Role of striatal cholinergic interneurons in set-shifting in the rat.

Aoki S, Liu A, Zucca A, Zucca S, Wickens J (2015) Role of striatal cholinergic interneurons in set-shifting in the rat. J Neurosci 35:9424-9431. doi: 10.1523/JNEUROSCI.0490-15.2015 Summary: The authors examined the role that cholinergic interneurons in the striatum play in a process called strategy set-shifting, where an attentional shift is required. Rats received bilateral injections

Role of striatal cholinergic interneurons in set-shifting in the rat. Read More »

Selective optogenetic stimulation of the retrotrapezoid nucleus in sleeping rats activates breathing without changing blood pressure or causing arousal or sighs.

Burke P, Kanbar R, Viar K, Stornetta R, Guyenet P (2015) Selective optogenetic stimulation of the retrotrapezoid nucleus in sleeping rats activates breathing without changing blood pressure or causing arousal or sighs. J Appl Physiol (1985) 118:1491-1501. doi: 10.1152/japplphysiol.00164.2015 Summary: Hypoxia and hypercapnia both play roles in the activation of normal breathing. If either one

Selective optogenetic stimulation of the retrotrapezoid nucleus in sleeping rats activates breathing without changing blood pressure or causing arousal or sighs. Read More »

Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133-saporin by photochemical internalization – A minimally invasive cancer stem cell-targeting strategy.

Bostad M, Olsen C, Peng Q, Berg K, Høgset A, Selbo P (2015) Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133-saporin by photochemical internalization – A minimally invasive cancer stem cell-targeting strategy. J Control Release 206:37-48. doi: 10.1016/j.jconrel.2015.03.008 Summary: Previously the authors demonstrated the use of photochemical internalization of a custom conjugate consisting of

Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133-saporin by photochemical internalization – A minimally invasive cancer stem cell-targeting strategy. Read More »

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