Aoki S, Liu A, Zucca A, Zucca S, Wickens J (2015) Role of striatal cholinergic interneurons in set-shifting in the rat. J Neurosci 35:9424-9431. doi: 10.1523/JNEUROSCI.0490-15.2015
Summary: The authors examined the role that cholinergic interneurons in the striatum play in a process called strategy set-shifting, where an attentional shift is required. Rats received bilateral injections of Anti-ChAT-SAP (Cat. #IT-42) into either the dorsomedial striatum or ventral striatum (500 ng total). Initial task learning was unaffected by either lesion. Lesioned animals displayed set-shifting deficits, and the deficit characteristics depended on the location of the lesion.
Related Products: Anti-ChAT-SAP (Cat. #IT-42)