Riazifar H, Sun G, Wang X, Rupp A, Vemaraju S, Ross-Cisneros F, Lang R, Sadun A, Hattar S, Guan M, Huang T (2015) Phenotypic and functional characterization of Bst+/- mouse retina. Dis Model Mech 8:969-976. doi: 10.1242/dmm.018176 PMID: 26035379 Summary: The belly spot and tail mutant mouse strain was first reported on in 1976. Among […]
Phenotypic and functional characterization of Bst+/- mouse retina. Read More »
Oyamaguchi A, Abe T, Sugiyo S, Niwa H, Takemura M (2016) Selective elimination of isolectin B4-binding trigeminal neurons enhanced formalin-induced nocifensive behavior in the upper lip of rats and c-Fos expression in the trigeminal subnucleus caudalis. Neurosci Res 103:40-47. doi: 10.1016/j.neures.2015.07.007 Summary: In adult rats non-peptidergic neurons and peptidergic neurons innervate different areas and layers
Rust A, Hassan HH, Sedelnikova S, Niranjan D, Hautbergue G, Abbas SA, Partridge L, Rice D, Binz T, Davletov B (2015) Two complementary approaches for intracellular delivery of exogenous enzymes. Sci Rep 5:12444. doi: 10.1038/srep12444 PMID: 26207613 Summary: Botulinum-derived proteases can be easily delivered into neuroendocrine cells using certain DNA lipofection reagents, revealing a novel
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King T, Ruyle B, Kline D, Heesch C, Hasser E (2015) Catecholaminergic neurons projecting to the paraventricular nucleus of the hypothalamus are essential for cardiorespiratory adjustments to hypoxia. Am J Physiol Regul Integr Comp Physiol 309:R721-731. doi: 10.1152/ajpregu.00540.2014 Summary: Catecholaminergic neurons in the brainstem are known to be involved in cardiorespiratory control and to modulate
While recombinant IB4-SAP (rIB4-SAP, Cat. #IT-10) has traditionally been used to eliminate cell populations that display alpha-D-galactose on the cell membrane, such as non-peptidergic c-fiber nociceptor neurons, it has also been found to be a very effective way to create stable transfected cell lines without the use of drug resistance genes. A recent publication by
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Saporin conjugates specifically eliminate cells identified by an extracellular marker. Each week we release new products for beta testing, so check out the website frequently. There are two conjugate configurations for Beta products. The first is a direct conjugate of the targeting agent to saporin; the second is a bonded toxin between the targeting agent
Targeting Tools: Beta Products. Great Opportunity for Discovery at a Very Low Price. Read More »
Q: For in vitro cytotoxicity assays, could you tell me: 1) whether you incubate primary with your Saporin secondary for a specific amount of time prior to cell addition, and 2) do you use a single concentration of secondary per well or a primary:secondary ratio — like 1:2 or 1:4? A: The primary antibody should
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Akiyama T, Nguyen T, Curtis E, Nishida K, Devireddy J, Delahanty J, Carstens M, Carstens E (2015) A central role for spinal dorsal horn neurons that express neurokinin-1 receptors in chronic itch. Pain 156:1240-1246. doi: 10.1097/j.pain.0000000000000172 Summary: Chronic itch is caused by increased sensitivity of itch-signaling pathways. It can be generated by normally itchy stimuli
Noe C, McDermott E (2015) Featured Article: SP-SAP human clinical trial for cancer pain – an anesthesiologist’s point of view. Targeting Trends 16(3) Related Products: SP-SAP (Cat. #IT-07) Read the featured article in Targeting Trends.