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  4. Selective elimination of isolectin B4-binding trigeminal neurons enhanced formalin-induced nocifensive behavior in the upper lip of rats and c-Fos expression in the trigeminal subnucleus caudalis.

Selective elimination of isolectin B4-binding trigeminal neurons enhanced formalin-induced nocifensive behavior in the upper lip of rats and c-Fos expression in the trigeminal subnucleus caudalis.

Oyamaguchi A, Abe T, Sugiyo S, Niwa H, Takemura M (2016) Selective elimination of isolectin B4-binding trigeminal neurons enhanced formalin-induced nocifensive behavior in the upper lip of rats and c-Fos expression in the trigeminal subnucleus caudalis. Neurosci Res 103:40-47. doi: 10.1016/j.neures.2015.07.007

Summary: In adult rats non-peptidergic neurons and peptidergic neurons innervate different areas and layers of the lamina. It is thought that these two neuronal populations play different roles in nociceptive processing, but the specific function of each group is not well understood. In order to investigate peptidergic and non-peptidergic neurons in orofacial pain processing the authors injected the cisterna magna of rats with 2.9 μg of rIB4-SAP (Cat. #IT-10). Blank-SAP (Cat. #IT-21) was used as a control. The lesioned animals displayed more frequent face-rubbing responses on the administration of formalin, indicating that IB4-binding neurons in the trigeminal nerve play an anti-nociceptive role in response to this type of pain.

Related Products: IB4-SAP (Cat. #IT-10), Blank-SAP (Cat. #IT-21)