Author name: Kristen Hartman

Hindbrain catecholamine neurons activate orexin neurons during systemic glucoprivation in male rats.

Li A, Wang Q, Elsarelli M, Brown R, Ritter S (2015) Hindbrain catecholamine neurons activate orexin neurons during systemic glucoprivation in male rats. Endocrinology 156:2807-2820. doi: 10.1210/en.2015-1138 Summary: Norepinephrine and epinephrine-secreting catecholamine neurons are strong stimulators of food intake. The authors investigated the interaction between these catecholamine neurons and orexin neurons in the perifornical lateral […]

Hindbrain catecholamine neurons activate orexin neurons during systemic glucoprivation in male rats. Read More »

Endogenous opioid activity in the anterior cingulate cortex is required for relief of pain.

Navratilova E, Xie J, Meske D, Qu C, Morimura K, Okun A, Arakawa N, Ossipov M, Fields H, Porreca F (2015) Endogenous opioid activity in the anterior cingulate cortex is required for relief of pain. J Neurosci 35:7264-7271. doi: 10.1523/JNEUROSCI.3862-14.2015 Summary: There are a number of neuronal circuits involved in the processing of pain, including

Endogenous opioid activity in the anterior cingulate cortex is required for relief of pain. Read More »

Respiratory function after selective respiratory motor neuron death from intrapleural CTB-saporin injections.

Nichols N, Vinit S, Bauernschmidt L, Mitchell G (2015) Respiratory function after selective respiratory motor neuron death from intrapleural CTB-saporin injections. Exp Neurol 267:18-29. doi: 10.1016/j.expneurol.2014.11.011 Summary: Amyotrophic lateral sclerosis (ALS) ultimately causes death from ventilator failure. Genetic models of ALS suffer from high variability of the rate, timing, and extent of respiratory motor neuron

Respiratory function after selective respiratory motor neuron death from intrapleural CTB-saporin injections. Read More »

Novel mechanisms of spinal cord plasticity in a mouse model of motoneuron disease.

Gulino R, Parenti R, Gulisano M (2015) Novel mechanisms of spinal cord plasticity in a mouse model of motoneuron disease. Biomed Res Int 2015:654637. doi: 10.1155/2015/654637 Summary: Here the authors investigate spinal plasticity mechanisms involving a number of different proteins, including BDNF, Shh, Notch-1, Numb, and Noggin. The model used is a mouse motoneuron depletion

Novel mechanisms of spinal cord plasticity in a mouse model of motoneuron disease. Read More »

TRPV1 expression level in isolectin B₄-positive neurons contributes to mouse strain difference in cutaneous thermal nociceptive sensitivity.

Ono K, Ye Y, Viet C, Dang D, Schmidt B (2015) TRPV1 expression level in isolectin B₄-positive neurons contributes to mouse strain difference in cutaneous thermal nociceptive sensitivity. J Neurophysiol 113:3345-3355. doi: 10.1152/jn.00973.2014 Summary: In order to determine whether IB4-positive trigeminal sensory neurons affect pain sensitivity, the authors administered 2 μg of rIB4-SAP (Cat. #IT-10)

TRPV1 expression level in isolectin B₄-positive neurons contributes to mouse strain difference in cutaneous thermal nociceptive sensitivity. Read More »

Targeted Toxin Format

Q: I ordered a targeted toxin. Will it come in powder form? How do I re-dissolve it? A: Our Saporin conjugate products are all provided in sterile PBS solution within a concentration range of 0.5 – 3 mg/ml. Saporin is an extremely safe ‘toxin’ to handle in standard laboratory environments when in solution for several

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Role of adrenomedullin in the cerebrospinal fluid-contacting nucleus in the modulation of immobilization stress.

Wu Y, Song S, Liu H, Xing D, Wang X, Fei Y, Li G, Zhang C, Li Y, Zhang L (2015) Role of adrenomedullin in the cerebrospinal fluid-contacting nucleus in the modulation of immobilization stress. Neuropeptides 51:43-54. doi: 10.1016/j.npep.2015.03.007 Summary: The CSF-contacting nucleus (CSF-CN) is a brain structure containing neurons that can bidirectionally transmit signals

Role of adrenomedullin in the cerebrospinal fluid-contacting nucleus in the modulation of immobilization stress. Read More »

Anti-DBH-SAP specificity

Q: I’m interested in your anti-DBH-saporin toxin for lesioning central catecholaminergic neurons. I see from the product description that the antibody used is a mouse monoclonal – designed to specifically target rat DBH. My interest is to produce targeted lesions in mouse transgenic. Will this product still work specifically? Thanks. A: Unfortunately, we do not

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