Author name: Kristen Hartman

Intratumoral anti-HuD immunotoxin therapy for small cell lung cancer and neuroblastoma.

Ehrlich D, Wang B, Lu W, Dowling P, Yuan R (2014) Intratumoral anti-HuD immunotoxin therapy for small cell lung cancer and neuroblastoma. J Hematol Oncol 7:91. doi: 10.1186/s13045-014-0091-3 Summary: HuD protein is a 40-kDa neuronal RNA-binding protein that is expressed in 100% of small cell lung cancer (SCLC) tumor cells. An anti-HuD monoclonal was biotinylated […]

Intratumoral anti-HuD immunotoxin therapy for small cell lung cancer and neuroblastoma. Read More »

GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain.

Keimpema E, Zheng K, Barde SS, Berghuis P, Dobszay MB, Schnell R, Mulder J, Luiten PG, Xu ZD, Runesson J, Langel U, Lu B, Hokfelt T, Harkany T (2014) GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain. Cereb Cortex 24(12):3277-3288. doi: 10.1093/cercor/bht192 Summary: In this work the

GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain. Read More »

A combination of targeted toxin technology and the piggyBac-mediated gene transfer system enables efficient isolation of stable transfectants in nonhuman mammalian cells.

Sato M, Inada E, Saitoh I, Matsumoto Y, Ohtsuka M, Miura H, Nakamura S, Sakurai T, Watanabe S (2015) A combination of targeted toxin technology and the piggyBac-mediated gene transfer system enables efficient isolation of stable transfectants in nonhuman mammalian cells. Biotechnol J 10:143-153. doi: 10.1002/biot.201400283 Summary: In this work the authors developed a new

A combination of targeted toxin technology and the piggyBac-mediated gene transfer system enables efficient isolation of stable transfectants in nonhuman mammalian cells. Read More »

Treatment considerations for cancer pain: A global perspective.

Pergolizzi J, Gharibo C, Ho K (2015) Treatment considerations for cancer pain: A global perspective. Pain Pract 15:778-792. doi: 10.1111/papr.12253 Summary: This review discusses the treatment of cancer pain, addressing various aspects of the overall picture, such as early pain treatment to reduce central sensitization and chronic pain, pain assessment tools, and guidelines for treating specific

Treatment considerations for cancer pain: A global perspective. Read More »

NK1-receptor-expressing paraventricular nucleus neurones modulate daily variation in heart rate and stress-induced changes in heart rate variability.

Feetham C, Barrett-Jolley R (2014) NK1-receptor-expressing paraventricular nucleus neurones modulate daily variation in heart rate and stress-induced changes in heart rate variability. Physiol Rep 2:e12207. doi: 10.14814/phy2.12207 Summary: Neurons in the paraventricular nucleus (PVN) project to the medulla and spinal cord, regulating heart rate and blood pressure. Although the activity of these neurons becomes elevated

NK1-receptor-expressing paraventricular nucleus neurones modulate daily variation in heart rate and stress-induced changes in heart rate variability. Read More »

Brainstem opioidergic system is involved in early response to experimental SAH.

Cetas J, McFarlane R, Kronfeld K, Smitasin P, Liu J, Raskin J (2015) Brainstem opioidergic system is involved in early response to experimental SAH. Transl Stroke Res 6:140-147. doi: 10.1007/s12975-014-0378-2 Objective: To determine the cause of poor long-term outcomes after Subarachnoid hemorrhage (SAH). Summary: Failure of the RVM μ-opioid receptor cells to initiate the compensatory

Brainstem opioidergic system is involved in early response to experimental SAH. Read More »

SFN Poster of the Year 2014

Meetings Abstracts /

Congratulations to this year’s winner of ATS’ Poster of the Year featuring IT-42 Anti-ChAT-SAP. Be sure to check out the featured article in Targeting Trends. 692.21 Impairments in gait, posture and complex movement control in rats modeling the multi-system, cholinergic-dopaminergic losses in PDK Phillips, A Kucinski, R Albin, M Sarterfeaturing IT-42 Anti-ChAT-SAP (poster; Wednesday, Nov. 19,

SFN Poster of the Year 2014 Read More »

Is selective hippocampal cholinergic deafferentation sufficient to produce temporally graded retrograde amnesia?

Köppen JR, Stuebing SS, Sieg M, Blackwell AA, Blankenship P, Grisley ED, Cheatwood JL, Wallace DG (2014) Is selective hippocampal cholinergic deafferentation sufficient to produce temporally graded retrograde amnesia?. Neuroscience 2014 Abstracts 749.20. Society for Neuroscience, Washington, DC. Summary: Dementia of the Alzheimer’s type (DAT) is a neurodegenerative disorder marked by degeneration of basal forebrain

Is selective hippocampal cholinergic deafferentation sufficient to produce temporally graded retrograde amnesia? Read More »

The galantamine prodrug, Memogain®, reverses deficits in hippocampal neurogenesis associated with the loss of basal forebrain cholinergic neurons

Van Kampen JM, Kay DG, Maelicke A (2014) The galantamine prodrug, Memogain®, reverses deficits in hippocampal neurogenesis associated with the loss of basal forebrain cholinergic neurons. Neuroscience 2014 Abstracts 789.21. Society for Neuroscience, Washington, DC. Summary: Loss of basal forebrain cholinergic innervation of the hippocampus and severe neuronal loss within the hippocampal CA1 region are

The galantamine prodrug, Memogain®, reverses deficits in hippocampal neurogenesis associated with the loss of basal forebrain cholinergic neurons Read More »

The effects of targeted intracerebral saporin injection on recovery from stroke

Becker A, Goldberg M (2014) The effects of targeted intracerebral saporin injection on recovery from stroke. Neuroscience 2014 Abstracts 800.09. Society for Neuroscience, Washington, DC. Summary: It is well known that the diffuse neuromodulatory systems of the brain play a role in cortical plasticity that may extend to cortical reorganization after brain injury. The basal

The effects of targeted intracerebral saporin injection on recovery from stroke Read More »

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