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  4. Selective C1 lesioning slightly decreases angiotensin II type I receptor expression in the rat rostral ventrolateral medulla (RVLM).

Selective C1 lesioning slightly decreases angiotensin II type I receptor expression in the rat rostral ventrolateral medulla (RVLM).

Bourassa E, Stedenfeld K, Sved A, Speth R (2015) Selective C1 lesioning slightly decreases angiotensin II type I receptor expression in the rat rostral ventrolateral medulla (RVLM). Neurochem Res 40:2113-2120. doi: 10.1007/s11064-015-1649-3

Summary: Exogenous angiotensin II administered to the RVLM produces a significant pressor response that can be countered by angiotensin II type I receptor antagonists. In this work the authors examined the relative contribution of C1 and non-C1 neurons in the RVLM to this angiotensin II response. Rats received 10 or 15 ng of Anti-DBH-SAP (Cat. #IT-03) as unilateral injections into the RVLM. Mouse IgG-SAP (Cat. #IT-18) was used as control. The data indicate that the majority of angiotensin II type 1 receptors are expressed on non-C1 neurons or glia.

Related Products: Anti-DBH-SAP (Cat. #IT-03), Mouse IgG-SAP (Cat. #IT-18)