Chua J, Vankemmelbeke M, McIntosh R, Clarke P, Moss R, Parsons T, Spendlove I, Zaitoun A, Madhusudan S, Durrant L (2015) Monoclonal antibodies targeting LecLex-related glycans with potent antitumor activity. Clin Cancer Res 21:2963-2974. doi: 10.1158/1078-0432.CCR-14-3030
Summary: In this work the authors characterized two monoclonal antibodies that target glycans containing Lewis carbohydrate antigens. One of the methods used was to combine varying concentrations of the antibodies with 50 ng mouse Fab-ZAP (Cat. #IT-48) and apply the conjugates to cells for 72 hours. The antibodies were demonstrated to have efficient internalization, supported by potent in vivo anti-tumor activity.
Related Products: Fab-ZAP mouse (Cat. #IT-48)