Author name: Kristen Hartman

Noradrenergic hypothesis linking neurodegeneration-based cognitive decline and astroglia.

Leanza G, Gulino R, Zorec R (2018) Noradrenergic hypothesis linking neurodegeneration-based cognitive decline and astroglia. Front Mol Neurosci 11:254. doi: 10.3389/fnmol.2018.00254 Objective: To examine noradrenergic dysfunction in AD-related cognitive decline in humans and its potential involvement in AD pathology and disease progression. Summary: The authors discuss noradrenergic dysfunction in AD-related cognitive decline. The research focuses […]

Noradrenergic hypothesis linking neurodegeneration-based cognitive decline and astroglia. Read More »

Involvement of median preoptic nucleus and medullary noradrenergic neurons in cardiovascular and sympathetic responses of hemorrhagic rats

Naves LM, Marques SM, Mourão AA, Fajemiroye JO, Xavier CH, de Castro CH, Rebelo ACS, Rosa DA, Gomes RM, Colombari E, Pedrino GR (2018) Involvement of median preoptic nucleus and medullary noradrenergic neurons in cardiovascular and sympathetic responses of hemorrhagic rats. Sci Rep 8:11276. doi: 10.1038/s41598-018-29310-z Objective: To evaluate the involvement of median preoptic nucleus

Involvement of median preoptic nucleus and medullary noradrenergic neurons in cardiovascular and sympathetic responses of hemorrhagic rats Read More »

Targeting ChAT – An innovative tool to Study Alzheimer’s Disease

Targeting Topics /

Choline acetyltransferase (ChAT) catalyzes the synthesis of the neurotransmitter acetylcholine (ACh) from choline and acetyl-CoA in cholinergic neurons. ChAT serves as a specific marker for cholinergic neurons in both peripheral and central nervous systems. Dysfuntion of cholinergic neurons underlies aspects of clinical symptoms found in neurological and psychiatric disorders such as Alzheimer’s disease, Down and

Targeting ChAT – An innovative tool to Study Alzheimer’s Disease Read More »

Behavioral effects of immunotoxin 192IgG-saporin depends on the type of its administration to rats.

Dobryakova Y, Bolshakov A, Zaichenko M, Stepanichev M, Markevich V (2018) Behavioral effects of immunotoxin 192IgG-saporin depends on the type of its administration to rats. FENS 2018 Abstracts F055. Federation of European Neuroscience Societies, Berlin, Germany. Summary: It is known that degeneration of cholinergic neurons is one of key events during development of Alzheimer’s disease.

Behavioral effects of immunotoxin 192IgG-saporin depends on the type of its administration to rats. Read More »

Improvements in cognitive function after focused ultrasound are associated with changes in hippocampal cholinergic activity and neurogenesis.

Shin J, Kong C, Lee J, Na YC, Chang WS, Chang JW (2018) Improvements in cognitive function after focused ultrasound are associated with changes in hippocampal cholinergic activity and neurogenesis. FENS 2018 Abstracts C038. Federation of European Neuroscience Societies, Berlin, Germany. Summary: Introduction: Alzheimer’s disease is irreversible and progressive neurodegenerative disorder that destroys memory and

Improvements in cognitive function after focused ultrasound are associated with changes in hippocampal cholinergic activity and neurogenesis. Read More »

Expression of NR2B subunit of the NMDA receptor and spatial long-term memory in medial septal lesioned rats

Kruashvili L, Dashniani M, Beselia G, Chkhikvishvili N (2018) Expression of NR2B subunit of the NMDA receptor and spatial long-term memory in medial septal lesioned rats. FENS 2018 Abstracts F038. Federation of European Neuroscience Societies, Berlin, Germany. Summary: The present study was designed to investigate the effect of selective immunolesions of cholinergic and GABA- ergic

Expression of NR2B subunit of the NMDA receptor and spatial long-term memory in medial septal lesioned rats Read More »

Effects of lesions of medial septal area on spatial short-term memory

Rusadze K, Sakandelidze R, Chighladze M (2018) Effects of lesions of medial septal area on spatial short-term memory. FENS 2018 Abstracts F044. Federation of European Neuroscience Societies, Berlin, Germany. Summary: In the present study electrolytic and the immunotoxins (192 IgG saporin and GAT1-SAP) lesions of medial septal area (MS) were used to investigate the importance

Effects of lesions of medial septal area on spatial short-term memory Read More »

Breathing regulation and blood gas homeostasis after near complete lesions of the retrotrapezoid nucleus in adult rats.

Souza GMPR, Kanbar R, Stornetta DS, Abbott SBG, Stornetta RL, Guyenet PG (2018) Breathing regulation and blood gas homeostasis after near complete lesions of the retrotrapezoid nucleus in adult rats. J Physiol 596(13):2521-2545. doi: 10.1113/JP275866 Objective: To test how important the retrotrapezoid nucleus (RTN) is to PCO2 homeostasis and breathing during sleep or wake. Summary:

Breathing regulation and blood gas homeostasis after near complete lesions of the retrotrapezoid nucleus in adult rats. Read More »

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