Author name: Kristen Hartman

Eriobotrya japonica ameliorates cardiac hypertrophy in H9c2 cardiomyoblast and in spontaneously hypertensive rats

Chiang JT, Badrealam KF, Shibu MA, Kuo CH, Huang CYA-Ohoo, Chen BC, Lin YM, Viswanadha VP, Kuo WW, Huang CY (2018) Eriobotrya japonica ameliorates cardiac hypertrophy in H9c2 cardiomyoblast and in spontaneously hypertensive rats. Environ Toxicol 33:1113-1122. doi: 10.1002/tox.22589 PMID: 29974613 Objective: To evaluate the prospective efficacy of E. japonica leave extract (EJLE) against Angiotensin-II […]

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Development and evaluation of T-Zap: a novel antibody-drug conjugate for the treatment of Her2 positive breast cancer

Hoffmann RM, Crescioli S, Thurston DE, Karagiannis SN (2018) Development and evaluation of T-Zap: a novel antibody-drug conjugate for the treatment of Her2 positive breast cancer. Cancer Res 78:LB-001. doi: 10.1158/1538-7445.AM2018-LB-001 PMID: 909090 Objective: Develop and Evaluate a novel ADC (T-Zap) for breast cancer. Summary: Binding to target cells of T-Zap was confirmed. Comparison of

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The effect and mechanism of chinese herbal formula Sini Tang in heart failure after myocardial infarction in rats

Zhu Y, Zhao J, Han Q, Wang Z, Wang Z, Dong X, Li J, Liu L, Shen X (2018) The effect and mechanism of chinese herbal formula Sini Tang in heart failure after myocardial infarction in rats. Evid Based Complement Alternat Med 2018:5629342. doi: 10.1155/2018/5629342 PMID: 30050591 Objective: To investigate the effectiveness and mechanism of

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Nitration and glycation turn mature NGF into a toxic factor for motor neurons: A role for p75

Kim M, Vargas M, Harlan B, Killoy K, Ball L, Comte-Walters S, Gooz M, Yamamoto Y, Beckman J, Barbeito L, Pehar M (2018) Nitration and glycation turn mature NGF into a toxic factor for motor neurons: A role for p75. Antioxid Redox Signal 28:1587-1602. doi: 10.1089/ars.2016.6966 PMID: 28537420 Related Products: NGFr (mu p75) Rabbit Polyclonal,

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Therapeutic Potential of Hematopoietic Stem Cell Gene Editing

Targeting Topics /

Gene therapy has been proposed for a variety of genetic disorders, including severe combined immunodeficiency, but it has not yet found routine use in the clinic, in part because of potential complications. To help pave the way for safer translation of such gene therapy, Schiroli et al. studied potential approaches to gene therapy in mouse

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SAT0058 Adalimumab: TNF complexes are cleared more efficiently by human osteoclasts than those with etanercept through FCG-receptor binding and internalisation

Harvey BP, Cohen-Solal J, Kaymakcalan Z (2018) SAT0058 Adalimumab: TNF complexes are cleared more efficiently by human osteoclasts than those with etanercept through FCG-receptor binding and internalisation. Ann Rheum Dis 77:893. EULAR 2018, Amsterdam, The Netherlands doi: 10.1136/annrheumdis-2018-eular.3804 Objective: To determine whether Fc-gamma receptor (FcgR)-mediated internalization of the biologic:TNF complexes is a contributing mechanism responsible

SAT0058 Adalimumab: TNF complexes are cleared more efficiently by human osteoclasts than those with etanercept through FCG-receptor binding and internalisation Read More »

Targeting Cancer PCI and Saporin conjugates

Targeting Topics /

Enhanced Targeting of Triple-Negative Breast Carcinoma and Malignant Melanoma by Photochemical Internalization of CSPG4-Targeting Immunotoxins. Eng MS, Kaur J, Prasmickaite L, Engesaeter BO, Weyergang A, Skarpen E, Berg K, Rosenblum MG, Maelandsmo GM, Hogset A, Ferrone S, & Selbo PK. (2018). Photochemical & Photobiological Sciences 17(5):539-551. Conclusion: The combination of the drug delivery technology PCI

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