Author name: Kristen Hartman

The embryotoxic effects of harm reduction tobacco products on osteoblasts developing from human embryonic stem cells

Sparks NR (2018) The embryotoxic effects of harm reduction tobacco products on osteoblasts developing from human embryonic stem cells. University of California Riverside Thesis. Objective: To investigate the effect of maternal smoking in the development of embryonic skeleton and the molecular mechanisms involved in skeletal embryotoxicity induced by conventional and harm-reduction tobacco. Summary: An in […]

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Gut vagal sensory signaling regulates hippocampus function through multi-order pathways.

Suarez AN, Hsu TM, Liu CM, Noble EE, Cortella AM, Nakamoto EM, Hahn JD, de Lartigue G, Kanoski SE (2018) Gut vagal sensory signaling regulates hippocampus function through multi-order pathways. Nat Commun 9(1):2181. doi: 10.1038/s41467-018-04639-1 Objective: To determine the  endogenous relevance of GIderived vagal HPC communication. Summary: Endogenous derived vagal sensory signaling promotes HPC-dependent memory

Gut vagal sensory signaling regulates hippocampus function through multi-order pathways. Read More »

An agonistic antibody to EPHA2 exhibits antitumor effects on human melanoma cells

Sakamoto A, Kato K, Hasegawa T, Ikeda S (2018) An agonistic antibody to EPHA2 exhibits antitumor effects on human melanoma cells. Anticancer Res 38:3273-3282. doi: 10.21873/anticanres.12592 Objective: Investigate the therapeutic potential of antibody to EPHA2 against melanoma in vitro. Summary: Observations indicate a promising role for EPHA2 as a target in antibody treatments for melanoma,

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Cholinesterase Inhibitors and Estrogen Receptor Expression

Targeting Topics /

Effects of Cholinergic Lesions and Cholinesterase Inhibitors on Aromatase and Estrogen Receptor Expression in Different Regions of the Rat Brain. Li J, Rao D, & Gibbs RB. Neuroscience Available online 29 May 2018 In Press, Uncorrected Proof. Highlights This paper applied a novel UPLC–MS/MS method to detect aromatase (ARO) activity in the brain tissue. Medial

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Engineering elastic properties into an anti-TNFα monoclonal antibody

Sadhukhan R, Brown N, Ouellette D, Banach D, Filoti DI, Winarta D, Raghavendra R, Sousa S, Darcy A, Alessandri L, Ivanov A, Bose S, Eaton L, Preston G, Freeman J, Correia I (2018) Engineering elastic properties into an anti-TNFα monoclonal antibody. Cogent Biol 4(1):1469387. doi: 10.1080/23312025.2018.1469387 Objective: To engineer elastic properties into a TNFalpha antibody.

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Targeting Pain

Targeting Topics /

Agents of Interest in Pain Research Agent Target Lesioning Use 192-IgG-SAPCat. #IT-01 p75NTR, low affinity NGFR(cholinergic basal forebrain, cerebellar Purkinje neurons,postganglionic autonomic neuronsand some primary sensory neurons) Immunolesioning Anti-DBH-SAPCat. #IT-03 Dopamine beta hydroxylase(adrenergic and noradrenergic neurons) Immunolesioning by applicationto either dendrites/soma orby retrograde axonal transport Anti-SERT-SAPCat. #IT-23 Sertonin transporter(serotonergic neurons) Immunolesioning Dermorphin-SAPCat. #IT-12 mu opioid receptor(striatal

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Survival of melanopsin expressing retinal ganglion cells long term after optic nerve trauma in mice

Sánchez-Migallón MC, Valiente-Soriano FJ, Nadal-Nicolás FM, Di Pierdomenico J, Vidal-Sanz M, Agudo-Barriuso M (2018) Survival of melanopsin expressing retinal ganglion cells long term after optic nerve trauma in mice. Exp Eye Res 174:93-97. doi: 10.1016/j.exer.2018.05.029 PMID: 29856984 Summary: Melanopsin-positive retinal ganglion cells (RGCs) do not respond to axotomy in the same way than the rest

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Direct conversion of mouse embryonic fibroblasts into neural crest cells

Motohashi T, Kunisada T (2019) Direct conversion of mouse embryonic fibroblasts into neural crest cells. (eds. Turksen K). In: Skin Stem Cells. Methods in Molecular Biology. 1879:307-321. Humana Press, New York, NY. doi: 10.1007/7651_2018_145 PMID: 29797008 Objective: To describe methods for the direct conversion of mouse embryonic fibroblasts into neural crest cells (NCCs). Summary: Sox10-IRES-Venus

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Disruption of medial septum and diagonal bands of Broca cholinergic projections to the ventral hippocampus disrupt auditory fear memory.

Staib JM, Della Valle R, Knox DK (2018) Disruption of medial septum and diagonal bands of Broca cholinergic projections to the ventral hippocampus disrupt auditory fear memory. Learn Mem 152:71-79. doi: 10.1016/j.nlm.2018.05.009 Objective: To determine which efferent projections are critical for contextual fear memory discrimination and extinction memory. Summary: The results of this study suggest

Disruption of medial septum and diagonal bands of Broca cholinergic projections to the ventral hippocampus disrupt auditory fear memory. Read More »

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