Cholinesterase Inhibitors and Estrogen Receptor Expression

Effects of Cholinergic Lesions and Cholinesterase Inhibitors on Aromatase and Estrogen Receptor Expression in Different Regions of the Rat Brain.

Li J, Rao D, & Gibbs RB. Neuroscience

Available online 29 May 2018 In Press, Uncorrected Proof.


  • This paper applied a novel UPLC–MS/MS method to detect aromatase (ARO) activity in the brain tissue.
  • Medial septum selective cholinergic lesion (192-IgG-SAP; Cat. #IT-01) did not regulate ARO and estrogen receptors (ERs) in the hippocampus.
  • Cholinesterase inhibitors injection has no influence on ARO and ERs in several brain regions.
  • Galantamine increased ARO activity with no change of ARO mRNA in the amygdala.
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