1. Home
  2. Knowledge Base
  3. References
  4. Disruption of medial septum and diagonal bands of Broca cholinergic projections to the ventral hippocampus disrupt auditory fear memory.

Disruption of medial septum and diagonal bands of Broca cholinergic projections to the ventral hippocampus disrupt auditory fear memory.

Staib JM, Della Valle R, Knox DK (2018) Disruption of medial septum and diagonal bands of Broca cholinergic projections to the ventral hippocampus disrupt auditory fear memory. Learn Mem 152:71-79. doi: 10.1016/j.nlm.2018.05.009

Objective: To determine which efferent projections are critical for contextual fear memory discrimination and extinction memory.

Summary: The results of this study suggest that MS/vDBB cholinergic neurons are critical for fear and extinction memory.

Usage: 192-IgG saporin was infused into all brain regions at a concentration of 0.2 μg/μL dissolved in 0.2 M PBS. The total volume of each injection was 0.5 μL. Sham surgeries were accomplished using the same volume (0.5 μL) of PBS.

Related Products: 192-IgG-SAP (Cat. #IT-01)