Read the 2016 newsletters and recent scientific references 2016, issue 1: Striatal patch compartment lesions reduce cocaine-induced repetitive behaviors / by KA Horner and collaborators R Murray and MC Logan Mercer / featuring Dermorphin-SAP (Cat. #IT-12) From the President: New Beginnings Targeting Talk: Safety of the Toxin Featured Products: Custom Conjugates 2016, issue 2: Cerebral […]
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By Jigna Rajesh Kumar, [a, b, c, d] Ramamoorthy Rajkumar, [a, b, c] Liying Corinne Lee, [a, b, c] Gavin S. Dawe [a, b, c, d][a] Dept Pharmacology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 117600, Singapore [b] Neurobiology and Ageing Programme, Life Sciences Institute, National University of
By Rahul Palchaudhuri, Ph.D., Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA Hematopoietic stem cell transplantation (HSCT) has been clinically used for 58 years and offers life-saving therapies for a variety of malignant and non-malignant blood disorders. Currently 50,000 transplants are performed globally per year with 90% of these for the
Anti-OX1R-SAP (Cat. #BETA-007) eliminates mouse, rat, and guinea pig cells expressing the orexin 1 receptor. All other cells are left untouched. Anti-OX2R-SAP (Cat. #BETA-008) eliminates rat cells expressing the orexin 2 receptor (OX2R). All other cells are left untouched. These two immunotoxins are being offered as part of our Beta Testing program. They have not
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ATS is pleased to re-release a product and kit specific for the Orexin 2 receptor (OX2R). The Orexin 1 and Orexin 2 receptors are found in the perifornical area/latero-posterior hypothalamus, and projections from this area cover much of the brain. These receptors have been implicated in various neurophysiological and neuropsychological disorders such as narcolepsy, insomnia,
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Wuzzup? No. What’s ZAP? Some of our products have SAP in the name, like 192-IgG-SAP (Cat. #IT-01). Some of our products have ZAP in the name, like Hum-ZAP (Cat. #IT-22). First, what’s the same about ZAP and SAP? They both mean Saporin. The payload that Advanced Targeting Systems made famous to specifically eliminate targeted cells.
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ATS is pleased to present a new product line specific for the vesicular GABA transporter (vGAT) protein. vGAT mediates both the accumulation of GABA into synaptic vesicles and its release from nerve terminals. vGAT is expressed in nerve endings of GABAergic neurons throughout the CNS. The GABAergic system is crucial to the development and functional
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CHOp75 Cells 192-IgG-SAP is the #1 rat p75-lesioning tool available for research use. Our development of CHOp75 cells grew from the need for a stable, reliable cell line to use for Quality Control of each new lot of 192-IgG-SAP. Now, these cells are available for use in laboratories worldwide. CHOp75 cells are standard CHO (Chinese
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The fundamental things apply. “The Peptidergic Control Circuit for Sighing,” recently published in the prestigious journal Nature, has made us rethink our fundamental belief that sighs are only “long, deep breaths expressing sadness, relief or exhaustion.” Often prompting someone to say, “What’s wrong?” As it turns out, sighs “also occur spontaneously every few minutes to
From the President: A Sigh is (Not) Just a Sigh . . . Read More »
by Ronald G. Wiley, M.D., Ph.D., Departments of Neurology and Pharmacology, Vanderbilt University, Nashville, TN and C. J. Vierck, Department of Neuroscience, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL, USA Degeneration of the cholinergic basal forebrain (CBF: medial septum, diagonal band of Broca, nucleus basalis of Meynert/substantia innominata) is a prominent