tt2016

Targeting Trends 2016 Newsletter

2016, issue 1: Striatal patch compartment lesions reduce cocaine-induced repetitive behaviors / by KA Horner and collaborators R Murray and MC Logan Mercer / featuring Dermorphin-SAP (Cat. #IT-12) From the President: New Beginnings Targeting Talk: Safety of the Toxin Featured Products: Custom Conjugates 2016, issue 2: Cerebral cholinergic lesion reduces operant responses to unpleasant thermal …

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Targeting Topics 16q4

Neural activity promotes long-distance, target-specific regeneration of adult retinal axons. Lim JH, Stafford BK, Nguyen PL, Lien BV, Wang C, Zukor K, He Z, Huberman AD. Nat Neurosci 19(8):1073-1084, 2016. PMID: 27399843 Axons in the CNS fail to regenerate after injury. Scientists sought to identify strategies that would allow retinal ganglion cell (RGC) axons to …

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Strategic Partners

This issue of Targeting Trends brings an exciting report of new partners that will bring more products, more expertise, and more service to our customers around the world. The primary purpose for making this change is to better facilitate the various functions that serve you, our customer. This restructure will also challenge and reward our …

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Cover Article: Targeted lesioning reveals role of nucleus incertus in the anxiogenic effect of buspirone

By Jigna Rajesh Kumar, [a, b, c, d] Ramamoorthy Rajkumar, [a, b, c] Liying Corinne Lee, [a, b, c] Gavin S. Dawe [a, b, c, d][a] Dept Pharmacology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 117600, Singapore [b] Neurobiology and Ageing Programme, Life Sciences Institute, National University of …

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Cover Article: Targeted depletion of hematopoietic stem cells promises safer transplantation

By Rahul Palchaudhuri, Ph.D., Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA Hematopoietic stem cell transplantation (HSCT) has been clinically used for 58 years and offers life-saving therapies for a variety of malignant and non-malignant blood disorders. Currently 50,000 transplants are performed globally per year with 90% of these for the …

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Targeting Topics 16q3

Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin. Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Tate TA, Czechowicz A, Kfoury Y, Ruchika F, Rossi DJ, Verdine GL, Mansour MK, Scadden DT. Nat Biotechnol 34(7):738-745, 2016. PMID: 27272386 see cover article Retinal Waves Modulate an Intraretinal Circuit of Intrinsically …

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Toolbox: Orexin-B-SAP

ATS is pleased to re-release a product and kit specific for the Orexin 2 receptor (OX2R). The Orexin 1 and Orexin 2 receptors are found in the perifornical area/latero-posterior hypothalamus, and projections from this area cover much of the brain. These receptors have been implicated in various neurophysiological and neuropsychological disorders such as narcolepsy, insomnia, …

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From the President: What’s ZAP?

Wuzzup? No. What’s ZAP? Some of our products have SAP in the name, like 192-IgG-SAP (Cat. #IT-01). Some of our products have ZAP in the name, like Hum-ZAP (Cat. #IT-22). First, what’s the same about ZAP and SAP? They both mean Saporin. The payload that Advanced Targeting Systems made famous to specifically eliminate targeted cells. …

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