tt2005

Targeting Trends 2005 Newsletter

Read the 2005 Newsletters 2005, issue 1: IB4-SAP Prevents Axotomy-Induced Sprouting of Aß Fibers / by Pearson M / featuring IB4-SAP (Cat. #IT-10) ATS Seeks Strategic Partner for Chronic Pain Drug SFN Poster of the Year Targeting Talk: Effective Toxins Targeting Tools: Anti-ChAT (Cat. #AB-N34 and AB-N34AP) 2005, issue 2: Noradrenergic inputs to the medial amygdala originate …

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Targeting Talk: Dose Ranging

We just completed surgeries where we implanted third ventricular cannulas and temporary bilatera cannulas directed into the nucleus tractus solitarius in the brainstem of animals. We injected either the Blank-SAP control toxin (Cat. #IT-21) or the experimental material Oxytocin-SAP into the bilateral NTS cannulae over a 30-second period. However, within the next week — two …

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Targeting Topics 05q4

Elimination of neurokinin-1 receptor neurons in caudal nucleus reverses the effects of systemic bicuculline on c-Fos expression in rat trigeminal sensory nucleus: I. High intensity electrical stimulation of the trigeminal ganglion. Abe T, Ohshita N, Sugiyo S, Moritani M, Kobayashi M, Takemura M. Neuroscience 133(3):739-747, 2005. The authors investigated the role of NK-1r + neurons …

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Cover Article: Effects of Intraseptal Orexin-Saporin on Spatial Memory

Contributed by Kevin Pang and Heidi Smith, Bowling Green State University, Dept Psychology, Bowling Green, Ohio Hypocretin (or orexin) neurons are located in the hypothalamus and have been implicated in various functions including sleep, arousal and feeding. One area receiving dense hypocretin projections and expressing hypocretin-2 receptors (H-2r) is the medial septum (MS), an area …

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Targeting Tools: SSTr1, SSTr5, NK-1r

Advanced Targeting Systems announces three new antibodies to G protein-coupled receptors that will be quite helpful for a number of researchers studying somatostatin and substance P. For somatostatin study, we already market excellent rabbit polyclonals to somatostatin-14 (Cat. #AB-04) and somatostatin-28 (Cat. #AB-05). We now announce a new mouse monoclonal antibody to somatostatin receptor 1 …

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Targeting Topics 05q3

CEACAM6 as a novel target for indirect type 1 immunotoxin-based therapy in pancreatic adenocarcinoma. Duxbury MS, Ito H, Ashley SW, Whang EE. Biochem Biophys Res Commun 317(3):837-843, 2004. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is a cell-surface molecule that is overexpressed in a variety of human cancers. Here, the authors investigate the efficacy of …

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Targeting Tools: Control Immunotoxins

One of the most important features of the Advanced Targeting Systems product line is the availability of control toxins that allow the researcher to fully evaluate results of the treatment of cells or animals with targeted toxins. For instance, anti-DBH-SAP is targeted with a mouse monoclonal antibody. Its control partner is mouse IgG-SAP, that is, …

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Targeting Topics 05q2

Basomedial hypothalamic injections of neuropeptide Y conjugated to saporin selectively disrupt hypothalamic controls of food intake. Bugarith K, Dinh TT, Li AJ, Speth RC, Ritter S. Endocrinology 146(3):1179-1191, 2005. Neurons in the arcuate nucleus (ARC) that coexpress neuropeptide-Y (NPY) and Agouti gene-related protein may be involved in glucoprivic feeding. The authors investigated the use of …

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