tt2005

Targeting Tools: Cy3-labeled Anti-murine NGFR

New Fluorescent Antibody: Cy3-labeled Anti-murine NGFr (Cat. #AB-N01APFL3) Advanced Targeting Systems introduces a new help in immunostaining: The antibody to mouse nerve growth factor receptor (NGFr, low affinity neurotrophin receptor, p75) conjugated to Cy3. The antibody is our widely-used rabbit polyclonal that has been affinity purified (Cat. #AB-N01AP). As can be seen in the figure …

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Cover Article: Effects of Intraseptal Orexin-Saporin on Spatial Memory

Contributed by Kevin Pang and Heidi Smith, Bowling Green State University, Dept Psychology, Bowling Green, Ohio Hypocretin (or orexin) neurons are located in the hypothalamus and have been implicated in various functions including sleep, arousal and feeding. One area receiving dense hypocretin projections and expressing hypocretin-2 receptors (H-2r) is the medial septum (MS), an area …

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Targeting Tools: SSTr1, SSTr5, NK-1r

Advanced Targeting Systems announces three new antibodies to G protein-coupled receptors that will be quite helpful for a number of researchers studying somatostatin and substance P. For somatostatin study, we already market excellent rabbit polyclonals to somatostatin-14 (Cat. #AB-04) and somatostatin-28 (Cat. #AB-05). We now announce a new mouse monoclonal antibody to somatostatin receptor 1 …

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Cover Article: Noradrenergic inputs to the medial amygdala originate in the A1 and A2 cells groups and release norepinephrine after mating stimulation sufficient to induce pseudopregnancy

Contributed by Lesley E. Northrop, Nicole Cameron and Mary Erskine, Department of Biology, Boston University The posterodorsal medial amygdala (MePD) is involved in processing the information from genito- sensory stimuli which is needed for mating-induced pseudopregnancy. The amygdala complex is known to be involved in memory storage and consolidation, processes known to be influenced by …

Cover Article: Noradrenergic inputs to the medial amygdala originate in the A1 and A2 cells groups and release norepinephrine after mating stimulation sufficient to induce pseudopregnancy Read More »

Targeting Tools: Anti-ChAT

ATS is pleased to present a polyclonal antibody specific for ChAT protein. Choline acetyltransferase (ChAT) catalyzes the synthesis of the neurotransmitter acetylcholine (ACh) from choline and acetyl-CoA in cholinergic neurons. ChAT serves as a specific marker for cholinergic neurons in both the peripheral and central nervous systems. Dysfunction of cholinergic neurons underlies aspects of clinical …

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ATS Seeks Strategic Partner for Chronic Pain Drug

Toxicology studies with the potential chronic pain therapeutic, SP-SAP (Substance P-Saporin) are continuing successfully. The second study will be initiated in a few months and ATS is diligently pursuing a pharmaceutical partner that can quickly bring the drug to clinical trials in humans. With the recent news of the undesirable side effects of such pain …

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Cover Article: IB4-SAP Prevents Axotomy-Induced Sprouting of Aß Fibers

Contributed by ATS’s 2004 Society for Neuroscience Poster of the Year Award Winner:Michelle Pearson, Purdue Pharma, Discovery Research, 6 Cedar Brook Drive, Cranbury NJ 08540 Neuropathic pain results in hyperalgesia and allodynia. It has been proposed that sprouting of myelinated touch-responsive Aβ-fibers into the innervation territory of pain-sensitive C-fibers in the spinal cord contributes to …

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