tt2002

Targeting Trends 2002 Newsletter

Read the 2002 Newsletters 2002, issue 1: Control Conjugates: The Perfect Companion for Targeted Toxins / by Lappi DA / featuring Control Conjugates SFN Poster of the Year Targeting Talk: Toxin Safety Targeting Tools: Serotonin Transporter Antibody 2002, issue 2: HCRT-SAP Lesion Produces Sleepiness While anti-DBH-SAP Lesion Does Not  / by Blanco-Centurion C / featuring Anti-DBH-SAP …

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Targeting Topics 02q4

Unilateral lesions of the cholinergic basal forebrain and fornix in one hemisphere and inferior temporal cortex in the opposite hemisphere produce severe learning impairments in rhesus monkeys. Easton A, Ridley RM, Baker HF, Gaffan D. Cereb Cortex 12(7):729-736, 2002. PMID: 12050084 The authors used a combination of basal forebrain lesioning using ME20.4-SAP (Cat. #IT-15) and …

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Cover Article: Does 192-IgG-Saporin or 5,7-DHT kill cognitive functions in the rat?

Contributed by Jean-Christophe Cassel, PhD, Laboratoire de Neurosciences Cognitives et Comportementales, UMR 7521 Université Louis Pasteur/CNRS, Strasbourg, France & Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Universität Freiburg, Neuropharmakologisches Labor, Freiburg, Germany. Dr. Cassel and colleagues are the authors of four publications released this quarter using 192-Saporin (Cat. #IT-01) Trying to understand how …

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Targeting Topics 02q3

Impairments in negative patterning, but not simple discrimination learning, in rats with 192 IgG-saporin lesions of the nucleus basalis magnocellularis. Butt AE, Noble MM, Rogers JL, Rea TE. Behav Neurosci 116(2):241-255, 2002. PMID: 11996310 192-Saporin (Cat. #IT-01) administration to the basal forebrain has frequently been used in rats to create a model for Alzheimer’s disease. …

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Cover Article: Saporin Immunotoxins for Treating Human Hematological Malignancies

Contributed by David J Flavell, PhD, The Simon Flavell Leukaemia Research Unit, Division of Cancer Sciences, University of Southampton Medical School, United Kingdom. I have asked Dr. Flavell to contribute an article on the clinical use of his saporin immunotoxins. Dr. Flavell’s research unit is named after his son, who died from leukemia. At that …

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Targeting Tools: OX7 and OX7-SAP

OX7-SAP is a cytotoxin to many types of neurons. It is one of the most potent of the saporin immunotoxins— the conjugates between a cell surface antibody and the ribosome-inactivating protein from Saponaria officinalis. The reason for the potency could be due to the construct’s grand tradition. The antibody, OX7, is one of the original …

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Targeting Topics 02q2

GABAergic septohippocampal neurons are not necessary for spatial memory. Pang KC, Nocera R, Secor AJ, Yoder RM. Hippocampus 11(6):814-827, 2001. PMID: 11811676 The medial septum and diagonal band of Broca (MSDB) are necessary for spatial memory. Both cholinergic and GABAergic neuronal populations are present in the MSDB. 192-Saporin (Cat. #IT-01) was used to eliminate cholinergic …

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Cover Article: HCRT-SAP Lesion Produces Sleepiness While anti-DBH-SAP Lesion Does Not

Carlos Blanco-Centurion contributes this report resulting from work done for an abstract at the 2001 Society for Neuroscience meeting: Hypocretin B-Saporin Lesions of the Brainstem Increase REM Sleep at Night CA Blanco- Centurion, RJ Salin-Pascual, D Gerashchenko, MA Greco, PJ Shiromani. Harvard Medical School & UNAM, Mexico City. This abstract won the ATS Abstract Award. …

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