Read the 2002 Newsletters and receint scientific references 2002, issue 1: Control Conjugates: The Perfect Companion for Targeted Toxins / by Lappi DA / featuring Control Conjugates SFN Poster of the Year Targeting Talk: Toxin Safety Targeting Tools: Serotonin Transporter Antibody 2002, issue 2: HCRT-SAP Lesion Produces Sleepiness While anti-DBH-SAP Lesion Does Not / by Blanco-Centurion […]
Targeting Trends 2002 Newsletter Read More »
Contributed by Jean-Christophe Cassel, PhD, Laboratoire de Neurosciences Cognitives et Comportementales, UMR 7521 Université Louis Pasteur/CNRS, Strasbourg, France & Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Universität Freiburg, Neuropharmakologisches Labor, Freiburg, Germany. Dr. Cassel and colleagues are the authors of four publications released this quarter using 192-Saporin (Cat. #IT-01) Trying to understand how
Cover Article: Does 192-IgG-Saporin or 5,7-DHT kill cognitive functions in the rat? Read More »
Advanced Targeting Systems announces the release of two reagents for immunological studies: Anti-Tac (Cat. # AB-18) – a monoclonal antibody to human CD25, the interleukin-2 receptor, and Anti-Tac-SAP (Cat. # IT-24) – the immunotoxin made by conjugation of anti-Tac to saporin. These reagents add to the growing list of ATS products for use in studies
Targeting Tools: Anti-Tac and Anti-Tac-SAP Read More »
Contributed by David J Flavell, PhD, The Simon Flavell Leukaemia Research Unit, Division of Cancer Sciences, University of Southampton Medical School, United Kingdom. I have asked Dr. Flavell to contribute an article on the clinical use of his saporin immunotoxins. Dr. Flavell’s research unit is named after his son, who died from leukemia. At that
Cover Article: Saporin Immunotoxins for Treating Human Hematological Malignancies Read More »
OX7-SAP is a cytotoxin to many types of neurons. It is one of the most potent of the saporin immunotoxins— the conjugates between a cell surface antibody and the ribosome-inactivating protein from Saponaria officinalis. The reason for the potency could be due to the construct’s grand tradition. The antibody, OX7, is one of the original
Targeting Tools: OX7 and OX7-SAP Read More »
Carlos Blanco-Centurion contributes this report resulting from work done for an abstract at the 2001 Society for Neuroscience meeting: Hypocretin B-Saporin Lesions of the Brainstem Increase REM Sleep at Night CA Blanco- Centurion, RJ Salin-Pascual, D Gerashchenko, MA Greco, PJ Shiromani. Harvard Medical School & UNAM, Mexico City. This abstract won the ATS Abstract Award.
Cover Article: HCRT-SAP Lesion Produces Sleepiness While anti-DBH-SAP Lesion Does Not Read More »
Advanced Targeting Systems announces a new reagent for the study of the serotonergic systems—a monoclonal antibody to the serotonin transporter (Cat. #AB-N09). This murine monoclonal is made with a peptide from an extracellular domain of rat serotonin re-uptake transporter (SERT), and thus is able to attach to cells that express SERT. Homology with the human
Targeting Tools: Serotonin Transporter Antibody Read More »
Dr. Douglas Lappi, Chief Scientific Officer, Advanced Targeting Systems The field of targeted toxins has made enormous strides in the years since Advanced Targeting Systems introduced the first research targeted toxin in 1994. We now offer 16 different targeted toxins, with more on the way. The number of important papers in high impact journals continues
Cover Article: Control Conjugates – The Perfect Companion for Targeted Toxins Read More »
Awarded by ATS at Society for Neuroscience (SFN) San Diego, CA • November 10-15, 2001 410.9 Hypocretin B-Saporin Lesions of the Brainstem Increase REM sleep at night. C.A.Blanco-Centurion*; R.J.Salin-Pascual; D.Gerashchenko; M.A.Greco; P.J.Shiromani featuring IT-20 Orexin-SAP (Poster) Loss of hypocretin (Hcrt) neurons has been linked to narcolepsy. These neurons project widely throughout brain, but it is
SFN Poster of the Year 2001 Read More »