IT-01: 192-IgG-SAP • Co-treatment with rivastigmine and idalopirdine reduces the propensity for falls in a rat model of falls in Parkinson’s disease. LID – 10.1007/s00213-018-5150-y [doi]. Koshy Cherian A et al. (2019). Psychopharmacol (Berl), [Epub ahead of print] Dose: Basal forebrain cholinergic neurons situated in the nucleus basalis and substantia innominata were targeted with […]
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Selective Cholinergic Depletion of Pedunculopontine Tegmental Nucleus Aggravates Freezing of Gait in Parkinsonian Rats. Xiao, H, Li, M, Cai, J, et al. (2017). Neurosci Lett [Epub 10 August 2017]. PMID: 28803956 Many patients with advanced Parkinson’s disease suffer from gait and postural impairments. The authors used Anti-ChAT-SAP (Cat. #IT-42) to specifically lesion neurons in the Pedunculopontine Tegmental Nucleus (PPTg) to examine the
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Isolectin B4 (IB4) is a tetrameric protein isolated from Griffonia simplicifolia seeds. Although one of its first uses was the agglutination of B-type red blood cells,[1] it has also been used extensively in the neurosciences because the alpha-galactosyl residues bound by IB4 are present on a variety of cell populations such as the non-peptidergic afferents
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Contributed by Dr. Naoki Yoshimura, Dept Urology/Pharmacology, Univ Pittsburgh School of Medicine, Pittsburgh PA 15213.Dr. Yoshimura summarizes his work with IB4-SAP. A complete report was published in Eur J Neurosci 20(2):474-482, 2004. It has been demonstrated that hyperexcitability of C-fibers in bladder afferent pathways can contribute to bladder overactivity and/or bladder pain under pathological conditions
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Internalization Technology to eliminate specific cells Advanced Targeting Systems’ technology – Molecular Surgery – is a modification of one of the most widely used techniques in the neurosciences: lesioning of a region by surgical means and observation of the effect. Saporin has no way of entering a cell on its own, except by bulk-phase endocytosis.
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GAT-1 is a sodium-coupled neurotransmitter transporter responsible for moving g-aminobutyric acid (GABA) across cell membranes. GABA is the predominant inhibitory neurotransmitter in the mammalian central nervous system. GAT-1 is widely distributed in both the central and peripheral nervous systems. GAT-1 and GABA are present in numerous neuronal pathways, some of which are implicated in epilepsy,
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In a study produced by Ferrini et al. indicates that morphine-induced hyperalgesia, as neuropathic pain, is a pathological alteration of pain sensitivity whose expression is gated by spinal microglia. Targeting at any level, this microglia-to-neuron cascade is a valuable strategy to improve the use of morphine in chronic pain. Ferrini F, Trang T, Mattioli TA,
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ATS has been awarded a Phase I SBIR grant to develop a new line of products. Dr. Douglas Lappi is the Principal Investigator and Brian Russell is the Lead Scientist on the project. Molecules targeted towards cell surface markers have been used for years to identify specific cell types. It has been demonstrated over the
Targeting Article: SBIR Grant Funded: Selective Activation in Neuronal Populations Read More »
Bombesin-SAP (Cat. #IT-40) Bombesin is a 14-amino-acid peptide found in frog-skin. The human equivalent, gastrin releasing peptide (GRP) has been detected in itch pathways and plays a role in eating behaviors. GRP regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation.
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TOOLS FOR SELECTIVELY ALTERING CELLS BASED ON CELL-SURFACE MARKERS You’re still publishing and we’re still open to meet your targeting needs. You can place your orders online or contact us. Stay safe and healthy!Denise Higginswww.ATSbio.com SERVICES FOR SELECTIVELY ALTERING AND ASSAYING CELLS Restricted access can slow or halt your research and drug development activities. We
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