To determine which subtype of nociceptor, peptidergic or non-peptidergic, is involved in the mechanical hyperalgesia induced by LMWH (low molecular weight hyaluronan), rats were pretreated with neurotoxins previously shown to selectively deplete these two types of sensory neurons:  Isolectin B4 (IB4)-saporin (SAP), which acts on IB4-positive, non-peptidergic neurons (Cat. #IT-10 IB4-SAP), and substance P-saporin (Cat.

To examine the role of NMBR+ dorsal horn neurons in itch and pain transmission, the authors treated mice with NMB-SAP (Cat. #IT-70; 2–3 μg, i.t.) at which no side effects were observed. NMB-SAP treated mice barely showed scratching behaviors, whereas control mice exhibited NMB-induced scratching with a rapid onset of scratching responses. These data demonstrate

Since 2000, Advanced Targeting Systems has presented an award each year at the Society for Neuroscience meeting for the best Poster of the Year using ATS targeting tools. This year the competition was fierce and some very exciting science was presented. Also, a big congratulations to the winner of the drawing for a $500 product

Gene therapy has been proposed for a variety of genetic disorders, including severe combined immunodeficiency, but it has not yet found routine use in the clinic, in part because of potential complications. To help pave the way for safer translation of such gene therapy, Schiroli et al. studied potential approaches to gene therapy in mouse

Congratulations to winners of the Nobel Prize in Physiology or Medicine 2017: Jeffrey C. Hall, Michael Rosbash, Michael W. Young for their discoveries of molecular mechanisms controlling the circadian rhythm. Circadian aspects of adipokine regulation in rodents. Challet E, Best Practice & Research Clinical Endocrinology & Metabolism (2017), doi: 10.1016/j.beem.2017.09.003. This paper reviews reciprocal links between the

Changes in the Secretory Activity of Organs Producing Noradrenaline Upon Inhibition of Its Synthesis in Neonatal Rat Brain. Murtazina, AR, Dilmukhametova, LK, Nikishina, YO, Sapronova, AY, Volina, EV, & Ugrumov, MV. (2017). Russian Journal of Developmental Biology, 48 (5):295-300. This study demonstrates that synthesis of noradrenaline after destruction of noradrenergic neurons was switched off by stereotactically