GAT1-SAP – BOGO

Study the physiological function of GABA neurons utilizing the targeted toxin GAT1-SAP!  GABA is the predominant inhibitory neurotransmitter in the mammalian central nervous system and plays a major role in sleep, reward consumption, fear aversion and locomotion among other things.

Figure shows number of GAD-positive neurons after treatment.  Maejima Y, Yokota S, Horita S, & Shimomura K. The undeveloped properties of GABA neurons in the ventral tegmental area promote energy intake for growth in juvenile rats. (2019). Sci Rep, 9 (1):11848.   
                               Control:  IT-35: Rabbit IgG-SAP

Objective:  To determine the underlying mechanisms that induce high energy intake (EI) per body weight (BW).
Summary:  Undeveloped properties of VTA GABA neurons in juvenile rats can promote higher EI regardless of high or less palatable feeding, and contribute to growth  promotion.
Dose:  GAT1-SAP or control, Rabbit IgG-SAP was bilaterally injected (0.025 μg/0.5 μl) into the VTA in eight-week-old adult rats.

Online orders only, enter GAT1bogo to receive one vial or kit free when you purchase one vial or kit of GAT1-SAP.
   Add 2 of the same size GAT1-SAP to the shopping cart and the second product will be credited by confirmation email.

GAT1-SAP [IT-32]; 
GAT1-SAP [KIT-32]  includes control conjugate

NOTE:  You may not see a discount in pricing at checkout, but correct pricing will be confirmed after you submit your order.

Tag-Targeted Toxin Thanks

Giving thanks to our wonderful customers, we’re offering a Thanksgiving discount on our Tag-Targeted Toxins!

Tag-Targeted Toxins use a secondary antibody to “piggyback” onto tagged recombinant proteins.  They can also be used to evaluate the expression of your tagged proteins in cells.

Anti-6 His-ZAP [IT-52]
a tool for eliminating 6 His-expressing cells or to “piggyback” onto your 6-His tagged proteins; targeted via mouse monoclonal antibody to 6 His, eliminated via saporin

Anti-FLAG (M5)-ZAP [IT-59]
a tool for eliminating FLAG (M5)-expressing cells or to “piggyback” onto your FLAG M5) tagged recombinant proteins; targeted via mouse monoclonal antibody to N-terminal Met-FLAG fusion protein, eliminated via saporin

Anti-GFP-ZAP [IT-53]
a tool for eliminating GFP-expressing cells; targeted via mouse monoclonal antibody to green fluorescent protein, eliminated via saporin

Anti-V5-ZAP [IT-58]
a tool for eliminating V5 epitope-expressing cells or to “piggyback” onto your V5 epitope-tagged recombinant proteins; targeted via mouse monoclonal antibody to V5 tag fusion protein, eliminated via saporin

For a limited time only:
Save 30% on purchase of any Tag-targeted toxin.

Enter coupon code TagTHANKS at checkout.
Your discount will be applied and confirmed via email.

Expires 30 November, 2019

Antibodies You Can Rely On!

The antibody AB-N33AP recognizes the NK-1 receptor.  The NK-1R, also known as the Substance P receptor, plays a significant role in pain and inflammation.

This antibody recognizes the NK-1 receptor in rat, dog and human.

For a limited time only:
Save 30% on purchase of this validated antibody.  Check out the references!

Enter coupon code NK1RBogo at checkout.
Your discount will be applied and confirmed via email.

Substance P receptor (NK-1R) [AB-N33AP]

Please let us know if we can answer any questions about this promotion or any of our antibodies.

Expires 30 November, 2019

Z-Kit Promotion

ZAP conjugates are non-targeted saporin conjugates that piggyback on to your primary targeting agent (antibody or biotinylated material).

Start November with a research tool with a trusted and proven track record.  The secondary conjugate that started them all, Mab-ZAP can be used for screening your mouse antibodies for selective binding and internalization.   
     Through the end of the month, buy any size ZAP Internalization Kit and receive a second kit of the same size for free.

Order online and use promo code:  ZAPit

Qualifying products:
chicken IgY:       Chick-ZAP  (KIT-62)
goat IgG:              Goat-ZAP (KIT-36)
guinea pig IgG:  gPIG-ZAP (KIT-64)
human IgG:         Hum-ZAP  (KIT-22); Fab-ZAP human  (KIT-51);
                                   FabFc-ZAP human  (KIT-65)
human IgM:        Hug-M-ZAP (KIT-43); Fab-ZAP Hug-M (KIT-78)
mouse IgG:         Mab-ZAP (KIT-04); Fab-ZAP mouse  (KIT-48)
mouse IgM:        Anti-M-ZAP (KIT-30)
rabbit IgG:          Rab-ZAP (KIT-05); Fab-ZAP rabbit (KIT-57)
rat IgG:                 Rat-ZAP (KIT-26);  Fab-ZAP rat (KIT-55)

biotinylated materials:  Streptavidin-ZAP
KIT-27-Ahu – human antibody
KIT-27-Amu – mouse antibody
KIT-27-Arb – rabbit antibody
KIT-27-Art – rat antibody

*Not good with any other promotion.  Due to the complex calculations involved in some promotion discounts, discount pricing will be verified after submission of online order.  The final pricing will be emailed to the purchaser for verification prior to shipping the order.

     Offer expires 30 November 2019.

 

Screen your antibodies pHast!

Screen your antibodies for binding and internalization in less than 24 hours with the next generation of high throughput antibody screening.

Fab-pHast is available for mouse and human antibody screening
Fab-pHast mouse (PH-02) and/or Fab-pHast human (PH-01).

NEW:  Streptavidin-pHast (PH-03) works with your biotinylated antibody.

Use promo code pHASTscreen when placing your ONLINE ORDER and save 30% on your Fab-pHast order!

Expires 31 December, 2019

Please let us know if we can answer any questions about this promotion or any of our products.

10% Off PLUS Free Shipping!

Order Online and receive 10% off your order of $100 or more PLUS free shipping!*

Use promo code:  FreeShip

Promotions on targeting tools are updated regularly.

Check back frequently or join our mailing list.

Click on My Account and register now.

  •  Maximum value of $80 for shipping; handling charge of $10 still applies.  Additional charges may be incurred for international shipments.
    *Not good with any other promotion.  Due to the complex calculations involved in some promotion discounts, discount pricing will be verified after submission of online order.  The final pricing will be emailed to the purchaser for verification prior to shipping the order.
  • NOTE:  credit card payments will incur a 3% surcharge.