Tag-targeted toxins are new conjugates in the Targeted Toxins family. Antibodies specific for tags on expressed proteins are bound to the ribosome-inactivating protein, saporin (from the seeds of the plant, Saponaria officinalis). The conjugate binds to your tag that is expressed on the cell surface and then internalizes by antibody-mediated endocytosis. Saporin breaks away from […]
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Contributed by Megan St. Peters and Martin Sarter Departments of Psychology at Ferrum College, Ferrum, VA and University of Michigan, Ann Arbor, MI Increasing attentional “effort” as a result of challenging circumstances, and as a function to maintain or recover attentional performance, is pervasive in our daily lives.[1] Attentional effort is more than a function
Read the 2011 Newsletters and recent scientific references 2011, issue 1: Targeted Lesion of Caudal Brainstem Catecholamine Neurons Reveals Their Role in Symptoms of Fatigue / by Goehler LE, Gaykema RPA / featuring Anti-DBH-SAP (Cat. #IT-03), Mouse IgG-SAP (Cat. #IT-18) SFN Poster of the Year Targeting Talk: Time Course for Toxins, Custom Mouse IgM Conjugate and
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Neurotensin is a 13 amino acid peptide found in the brain and spinal cord (first characterized by Carraway and Leeman1). It affects pituitary hormone release, interacts with the dopaminergic system, and is involved in vasodilation and hypotension. It can also modulate pain perception. Advanced Targeting Systems is pleased to announce two conjugates that will be
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Contributed by Tamara King and Frank Porreca Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA A common symptom of patients with neuropathic pain is spontaneous pain, often described as burning. Some patients also suffer from pain elicited by normally non-noxious stimuli, such as touch, referred to as allodynia. Preclinical studies have
Basic fibroblast growth factor (FGF-2) is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration
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Leptin is a 16-kDa peptide hormone secreted from white adipocytes and implicated in the regulation of food intake and energy balance. It provides the key afferent signal from fat cells in the feedback system that controls body fat stores. Leptin Human Recombinant, Cat. #PRP-228CYTavailable in these sizes: 200 micrograms, 1 milligram, and 5 milligrams Related
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Granulocyte Macrophage Colony Stimulating Factor (GM CSF) is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with
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Growth Hormone (GH) is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved
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by Leonardo R. Ancheta and Douglas A. Lappi, American Association of Cancer Research abstract #5218 Basigin-2 (EMMPRIN) is a marker for prognosis of several tumor types. With the identification of the internalization of basigin-2 in response to antibody binding, we now further explore the possibility of its use as a dynamic portal of entry for