IB4, or the B4 lectin isoform from Bandeiraea simplicifolia (Griffonia simplicifolia), has played an important role in the delineation of the pathways of pain transmission. One of the two major groups of primary afferents that target the spinal cord dorsal horn neurons are labeled by IB4; the other group by TrkA and peptides such as […]
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Contributed by Dr. Ann Schreihofer, University of Virginia, contributes this issue’s article from the laboratories of ATS customers. Dr. Schreihofer summarizes her research with anti-DBH-SAP (Cat. #IT-03) to immunolesion specific rostral ventral medulla neurons that project to the spinal cord by injection of anti-DBH-SAP into the rat spinal cord. The toxin is taken up and
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Read the 4th quarter, 2000 Newsletter and recent scientific references CBF Lesioning in Rabbits / by Beach T / featuring ME20.4-SAP, Cat. #IT-15 Chronic Pain Therapeutic NIDA funds ATS research on Galanin Targeting Talk: Second Immunotoxins Targeting Tools: New Products Mouse-Specific p75 Immunotoxin (Cat. #IT-16) ME20.4 Monoclonal and Immunotoxin (Cat. #IT-15, Cat. #AB-N07)
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The ME20.4 monoclonal antibody (Cat. #AB-N07) was derived from immunization of mice with WM245 melanoma cells. The antibody can be used in Western blot, immunoprecipitation, immunohistochemistry, FACS analysis, and electron microscopy. The known species reactivity includes human, primate, rabbit, raccoon, dog, cat, and sheep. The ME20.4-SAP immunotoxin (Cat. #IT-15) is a chemical conjugation between the
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The long-sought mouse cholinergic toxin has been found! The mouse cholinergic immunotoxin (Cat. #IT-16) is being released for sale at the Society for Neuroscience meeting in New Orleans, November 4-9, 2000! For years ATS has received requests for a molecule that would eliminate cholinergic neurons in the basal forebrain of mice in a manner that
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Advanced Targeting Systems (ATS) has just been awarded a $100,000 research grant from the National Institute on Drug Abuse (NIDA). This Phase I SBIR (Small Business Innovation Research) grant proposes to develop a research reagent to study the function of the neuropeptide, galanin. This will be an important tool for scientists to use in the
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Contributed by Dr. Thomas Beach, Sun Health Research Institute, Sun City, AZ Our hypothesis, developed through our own human and animal studies1-6 and the cell culture work of others (beginning with Nitsch7), is that the normal, age-related loss of cortical cholinergic innervation leads to Aβ deposition and Alzheimer’s disease. To test this hypothesis, we have been
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