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Streptavidin-ZAP evaluates antibodies for targeted tumor treatment

Characterization of the First Fully Human Anti-Tem1 Scfv in Models of Solid Tumor Imaging and Immunotoxin-Based Therapy. Yuan, X, Yang, M, Chen, X, et al. (2018). Cancer Immunol Immunother 2018/01/10. Streptavidin-ZAP (Cat. #IT-27) Objective: ScFv78 was conjugated with the ribosome-inactivating protein saporin (Streptavidin-ZAP) to evaluate whether scFv78 may be used as a vehicle for theTEM1-targeted […]

New publications: Melanopsin, Serotonin, Streptavidin

2018 starts off with 3 new publications using ATS products. Check out these articles and take advantage of special promotions for each of the products used. Melanopsin Retinal Ganglion Cells Are Not Labeled in Thy-1yfp-16 Transgenic Mice. Grillo, SL, & Stella, SL, Jr. (2018). Neuroreport, 29 (2):118-122. 2017/12/19. Objective: to determine whether mRGCs are labeled […]

Guillemin

Roger Guillemin honored by Université de Montréal

On December 5, 2017, Dr. Roger Guillemin was  honored by Université de Montréal by the naming of its assembly hall after him.  The honorary plaque will be installed at the entrance to the University Assembly hall, now re-named to mark the 40th anniversary of the French-born physician’s Nobel Prize for medicine. Salle Roger-Guillemin Born on […]

IB4-SAP to study mechanical hyperalgesia

To determine which subtype of nociceptor, peptidergic or non-peptidergic, is involved in the mechanical hyperalgesia induced by LMWH (low molecular weight hyaluronan), rats were pretreated with neurotoxins previously shown to selectively deplete these two types of sensory neurons:  Isolectin B4 (IB4)-saporin (SAP), which acts on IB4-positive, non-peptidergic neurons (Cat. #IT-10 IB4-SAP), and substance P-saporin (Cat. […]

UKflag

New Distributor in UK

We would like to welcome our newest partner: Stratech Scientific Limited The great team at Stratech will be serving customers in the United Kingdom. Denise Higgins President

Neuromedin B and Itch

To examine the role of NMBR+ dorsal horn neurons in itch and pain transmission, the authors treated mice with NMB-SAP (Cat. #IT-70; 2–3 μg, i.t.) at which no side effects were observed. NMB-SAP treated mice barely showed scratching behaviors, whereas control mice exhibited NMB-induced scratching with a rapid onset of scratching responses. These data demonstrate […]

Poster Award goes to Orexin-B

Since 2000, Advanced Targeting Systems has presented an award each year at the Society for Neuroscience meeting for the best Poster of the Year using ATS targeting tools. This year the competition was fierce and some very exciting science was presented. Also, a big congratulations to the winner of the drawing for a $500 product […]

Better Gene Therapy Through Targeting

Gene therapy has been proposed for a variety of genetic disorders, including severe combined immunodeficiency, but it has not yet found routine use in the clinic, in part because of potential complications. To help pave the way for safer translation of such gene therapy, Schiroli et al. studied potential approaches to gene therapy in mouse […]

Nobel Prize for Discoveries of Molecular Mechanisms of Circadian Rhythm

Congratulations to winners of the Nobel Prize in Physiology or Medicine 2017: Jeffrey C. Hall, Michael Rosbash, Michael W. Young for their discoveries of molecular mechanisms controlling the circadian rhythm. Circadian aspects of adipokine regulation in rodents. Challet E, Best Practice & Research Clinical Endocrinology & Metabolism (2017), doi: 10.1016/j.beem.2017.09.003. This paper reviews reciprocal links between the […]

Noradrenaline production reduced after treatment with Anti-DBH-SAP

Changes in the Secretory Activity of Organs Producing Noradrenaline Upon Inhibition of Its Synthesis in Neonatal Rat Brain. Murtazina, AR, Dilmukhametova, LK, Nikishina, YO, Sapronova, AY, Volina, EV, & Ugrumov, MV. (2017). Russian Journal of Developmental Biology, 48 (5):295-300. This study demonstrates that synthesis of noradrenaline after destruction of noradrenergic neurons was switched off by stereotactically […]