Targeting Trends

2020 Scientific References

Targeted Toxins Secondary Conjugates Control Conjugates Saporin Custom Conjugates Selected Antibodies Targeted Toxins: Targeting agent attached to Saporin IT-01 192-IgG-SAP Intracerebroventricular Administration of 192IgG-Saporin Alters the State of Microglia in the Neocortex. Volobueva MN, Dobryakova YV, Manolova AO, Stepanichev MY, Kvichansky AA, Gulyaeva NV, Markevich VA, Bolshakov AP Neurochem J 14(1):37-42, 2020.  doi: 10.1134/S1819712420010213 Objective: …

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Featured Saporin Conjugates

Antibody-Saporin Conjugates (able to be retrogradely transported) Saporin Conjugate(s) Molecular Target Cell Subpopulation Killed References 192-IgG-SAP(192-Saporin) Nerve growth factorreceptor (NGFR),p75NTR Rat cholinergic forebrainneuronsUpper cervical ganglion Cat. #IT-01 Anti-ChAT-SAP(ChAT-SAP) Cholineacetyltransferase(ChAT) Cholinergic interneurons ofdorsal striatum Cat. #IT-42 Anti-DAT-SAP(DAT-SAP) Dopamine Transporter(DAT) Dopaminergic neuronsParkinson’s disease Model Cat. #IT-25 Anti-DBH-SAP(DSAP) Dopamine betahydroxylase (DBH) Locus coeruleus/subcoeruleusAlzheimer’s disease Model Cat. #IT-03 Anti-GAT1-SAP(GAT1-SAP) …

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Targeting Trends 2019 Review

ATS and Cytologistics move to Carlsbad Targeted Ablation with SSP-SAP Scientific References Poster of the Year Custom Services with Cytologistics Top 20 Targeting Tools

Targeted ablation with SSP-SAP

Targeted hippocampal GABA neuron ablation produces hippocampal sclerosis, epilepsy, and dissociable effects on the Morris Water Maze and Object-Place Paired Association tasks by Argyle V. Bumanglag1, Leah M. Truckenbrod1, Eugene Chun2, Abbi R. Hernandez1, Quinten P. Federico1, Andrew P. Maurer1, Robert S. Sloviter3,4, Sara N. Burke1 1Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, …

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2019 Scientific References

Targeted Toxins Secondary Conjugates Selected Antibodies pHast Conjugates Custom Conjugates Targeted Toxins: Targeting agent attached to Saporin IT-01  192-IgG-SAP Co-treatment with rivastigmine and idalopirdine reduces the propensity for falls in a rat model of falls in Parkinson’s disease (2019) Koshy Cherian A, et al. Psychopharmacol (Berl) Basal forebrain chemogenetic inhibition disrupts the superior complex movement …

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Top 20 Targeting Tools of 2019

Top Five Targeted Toxins #1. CTB-SAP  (Cat. #IT-14) – targets cells expressing GM1 receptor #2. 192-IgG-SAP  (Cat. #IT-01) – targets cells expressing rat p75NTR #3. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase  #4. IB4-SAP (Cat. #IT-10) – targets cells expressing alpha-D-galactopyranoside residues #5. CCK-SAP (Cat. #IT-06) – targets cells expressing sulfonated Cholecystokinin Top Five …

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ATS and Cytologistics move to Carlsbad

Customer Service and know-how to help you with your next project. High quality products and services to increase your lab productivity. Next day shipping so you have the tools you need.

Cover Article: Targeted Toxins – Cheaper and Quicker than Knockouts

Cell-specific targeting and removal: cheaper and quicker than knockouts with high impact results. Knockout models are helpful tools in scientific research. They have been useful in studying and modeling in all sorts of research in biology; so much so that the pioneers – Smithies, Capecchi and Evans – won a well-deserved Nobel Prize for Physiology …

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Call for Proposals

Advanced Targeting Systems and its Contract Service partner, CytoLogistics announce a Call For Proposals for research collaborations on: Receptor-mediated Delivery: New Targets Selected researchers will receive support for smaller scale or pilot research projects ($1,000 – $25,000) with the targeting tools and contract services needed for the identification and characterization of new cell-surface markers for …

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Targeting Tools: Top Twenty of 2018

Top Five Targeted Toxins 1. CTB-SAP (Cholera Toxin B-Saporin) (Cat. #IT-14) – targets cells expressing GM1 receptor 2. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase (DBH) 3. 192-IgG-SAP (192-Saporin) (Cat. #IT-01) – targets cells expressing rat p75NTR 4. Anti-ChAT-SAP (Cat. #IT-42) – targets cells expressing choline acetyltransferase 5. Nppb-SAP (Neuropeptide natriuretic polypeptide …

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