Targeting Trends Newsletter

New Publications using Saporin conjugates

Cat. #IT-01  192-IgG-SAP Lesions of the nucleus basalis magnocellularis (Meynert) induce enhanced somatosensory responses and tactile hypersensitivity in rats. Dezawa S, Nagasaka K, Watanabe Y, & Takashima I. (2020). Exp Neurol, 335 113493. 2020/10/05.  Disruption of basal forebrain cholinergic neurons after traumatic brain injury does not compromise environmental enrichment-mediated cognitive benefits. Moschonas EH, Leary JB, …

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World Alzheimer’s Month – Latest publications

Cat. #IT-01  192-IgG-SAP Long-term potentiation in the hippocampal CA3 to CA1 synapses may be induced in vivo by activation of septal cholinergic inputs. Dobryakova, Y. V., M. Y. Stepanichev, V. A. Markevich and A. P. Bolshakov (2020).  Int J Neurosci: 1-9. Intracerebroventricular Administration of 192IgG-Saporin Alters the State of Microglia in the Neocortex. Volobueva, M. N., Y. …

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Featured Saporin Conjugates

Antibody-Saporin Conjugates (able to be retrogradely transported) Saporin Conjugate(s) Molecular Target Cell Subpopulation Killed References 192-IgG-SAP(192-Saporin) Nerve growth factorreceptor (NGFR),p75NTR Rat cholinergic forebrainneuronsUpper cervical ganglion Cat. #IT-01 Anti-ChAT-SAP(ChAT-SAP) Cholineacetyltransferase(ChAT) Cholinergic interneurons ofdorsal striatum Cat. #IT-42 Anti-DAT-SAP(DAT-SAP) Dopamine Transporter(DAT) Dopaminergic neuronsParkinson’s disease Model Cat. #IT-25 Anti-DBH-SAP(DSAP) Dopamine betahydroxylase (DBH) Locus coeruleus/subcoeruleusAlzheimer’s disease Model Cat. #IT-03 Anti-GAT1-SAP(GAT1-SAP) …

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Targeting Trends 2019 Review

ATS and Cytologistics move to Carlsbad Targeted Ablation with SSP-SAP Scientific References Poster of the Year Custom Services with Cytologistics Top 20 Targeting Tools Text editor

Targeted ablation with SSP-SAP

Targeted hippocampal GABA neuron ablation produces hippocampal sclerosis, epilepsy, and dissociable effects on the Morris Water Maze and Object-Place Paired Association tasks by Argyle V. Bumanglag1, Leah M. Truckenbrod1, Eugene Chun2, Abbi R. Hernandez1, Quinten P. Federico1, Andrew P. Maurer1, Robert S. Sloviter3,4, Sara N. Burke1 1Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, …

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2019 Scientific References

Targeted Toxins Secondary Conjugates Selected Antibodies pHast Conjugates Custom Conjugates Targeted Toxins: Targeting agent attached to Saporin IT-01  192-IgG-SAP Co-treatment with rivastigmine and idalopirdine reduces the propensity for falls in a rat model of falls in Parkinson’s disease (2019) Koshy Cherian A, et al. Psychopharmacol (Berl) Basal forebrain chemogenetic inhibition disrupts the superior complex movement …

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Top 20 Targeting Tools of 2019

Top Five Targeted Toxins #1. CTB-SAP  (Cat. #IT-14) – targets cells expressing GM1 receptor #2. 192-IgG-SAP  (Cat. #IT-01) – targets cells expressing rat p75NTR #3. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase  #4. IB4-SAP (Cat. #IT-10) – targets cells expressing alpha-D-galactopyranoside residues #5. CCK-SAP (Cat. #IT-06) – targets cells expressing sulfonated Cholecystokinin Top Five …

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Your back-up laboratory team is here

Assay and Conjugation Services Restricted access can slow or halt your research and drug development activities.  We can help!  Here is just one of the services CytoLogistics provides to research and drug development laboratories around the world.    Cell Transfections Transfections can be a time-consuming and tedious process.  Let CytoLogistics help you with the experimental …

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ATS and Cytologistics move to Carlsbad

Customer Service and know-how to help you with your next project. High quality products and services to increase your lab productivity. Next day shipping so you have the tools you need.